Drug or treatment

Binimetinib clinical trials

• 14Clinical trials
• 23Countries

Newest trials

All recruiting trials (14)

• Treatment for BRAF Mutant Melanoma with Brain Metastases

  This study tests a new combination treatment for people with BRAF-mutated melanoma that has spread to the brain to see if it helps them live longer without their cancer getting worse.

  Recruiting at 17 sites Phase 2 Grupo Español Multidisciplinar de Melanoma · A Coruña, A Coruña and 17 other locations · NCT06887088

• Monitoring the effects of encorafenib and binimetinib in melanoma treatment

  This study is testing how the levels of two melanoma drugs, encorafenib and binimetinib, affect side effects and treatment success in adults with a specific type of advanced melanoma.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt · NCT06774989

• Evaluating a new treatment for advanced colorectal cancer with specific genetic mutations

  This study is testing a new combination treatment for people with advanced colorectal cancer that has a specific genetic mutation to see if it can help them live longer and feel better.

  Recruiting Phase 2 Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) · Madrid · NCT06207656

• Using binimetinib for patients with specific types of brain and pancreatic cancer

  This study is testing if a medication called binimetinib can help people with specific types of brain and pancreatic cancer feel better and improve their condition.

  Recruiting at 6 sites Phase 2 National Cancer Center, Japan · Kashiwa, Chiba and 5 other locations · NCT06159478

• Treatment of pediatric adamantinomatous craniopharyngioma with MEKTOVI

  This study is testing if a new drug called MEKTOVI can help young patients with a tough brain tumor called adamantinomatous craniopharyngioma feel better and manage their condition.

  Recruiting at 10 sites Phase 2 Nationwide Children's Hospital · Aurora, Colorado and 9 other locations · NCT05286788

• Continued access to encorafenib and binimetinib for previous trial participants

  This study is for people who have previously taken the medications encorafenib and binimetinib and want to continue using them safely for up to five years if they are still benefiting from the treatment.

  Recruiting at 62 sites Phase 4 Pfizer · Phoenix, Arizona and 76 other locations · NCT05203172

• Combining ZEN003694 and Binimetinib for Advanced Solid Tumors with RAS Alterations

  This study is testing a combination of two cancer drugs, ZEN003694 and binimetinib, to see if they can help people with advanced solid tumors that have RAS changes.

  Recruiting Phase 1 National Cancer Institute (NCI) · Boston, Massachusetts and 3 other locations · NCT05111561

• Treatment of metastatic melanoma with binimetinib and encorafenib

  This study is testing if a combination of two medications can help people with a specific type of melanoma that has spread to the brain feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05026983

• Combining nilotinib with other drugs for treating metastatic melanoma

  This study is testing if adding nilotinib to existing treatments can help people with advanced melanoma that has a specific genetic mutation feel better and tolerate the drugs well.

  Recruiting at 3 sites Phase 1 University of Kentucky · Iowa City, Iowa and 3 other locations · NCT04903119

• Adjuvant therapy for melanoma based on treatment response

  This study tests if a combination of new medications can help people with melanoma who have a specific gene mutation stay cancer-free after their initial treatment.

  Recruiting Early Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT04741997

• Treatment for advanced KIT-mutant melanoma using binimetinib and imatinib

  This study is testing if a combination of two medications, binimetinib and imatinib, can help people with advanced KIT-mutant melanoma feel better and manage their disease.

  Recruiting at 2 sites Phase 2 University of California, San Francisco · La Jolla, California and 1 other locations · NCT04598009

• Comparing two treatment combinations for melanoma with brain metastases

  This study is testing two different treatment combinations for patients with melanoma that has spread to the brain to see which one helps them live longer without the disease getting worse.

  Recruiting at 303 sites Phase 2 SWOG Cancer Research Network · Birmingham, Alabama and 330 other locations · NCT04511013

• Treatment for Hairy Cell Leukemia Without BRAF Mutation

  This study is testing if a new drug called binimetinib can help people with hairy cell leukemia who don't have a BRAF mutation and haven't responded to other treatments.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04322383

• Investigation of encorafenib and binimetinib for advanced melanoma treatment

  This study looks at how well the combination of encorafenib and binimetinib works for people with advanced melanoma who have a specific genetic mutation and have already tried other treatments.

  Recruiting at 59 sites Pierre Fabre Pharma GmbH · Graz and 58 other locations · NCT04045691

Quick answers

How many clinical trials of Binimetinib are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (9 trials), Spain (3 trials), Germany (2 trials), Australia (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1: 2, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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