Condition

MDD clinical trials and research

• 12Clinical trials
• 1New in 30 days
• 7Countries

Newest MDD clinical trials

All recruiting trials (12)

• Sensation Seeking and TMS Response in TRD: Does Personality Shape Treatment Outcomes?

  This real-world study tests whether people with treatment-resistant depression who have higher sensation-seeking traits respond differently to TMS treatment.

  Recruiting Technical University of Munich · München, Bavaria · NCT07889739

• Sleep-to-Mood in Depression: Home-based tDCS

  This study tests whether home-based tDCS for adults with moderate depression helps sleep improve and whether better sleep is linked to mood improvements.

  Recruiting NYU Langone Health · New York, New York · NCT07572526

• Inhaled DMT for major depressive disorder

  This trial tests whether inhaled DMT can quickly ease depressive symptoms and reduce suicide risk in adults with major depressive disorder.

  Recruiting Phase 2 Universidade Federal do Rio Grande do Norte · Fortaleza, Ceará and 4 other locations · NCT07562191

• Omega‑3 (EPA) for depression linked to inflammation in adults with obesity

  This trial tests whether taking 2 g/day of EPA omega‑3 for 12 weeks helps reduce depressive symptoms in antidepressant‑free adults with obesity who have low omega‑3 levels.

  Recruiting National Science and Technology Council, Taiwan · Taichung, Taichung · NCT07439744

• How brain and symptom networks change with TMS for depressive syndrome

  This project will see if brain and symptom network measures and TMS stimulation sites can predict which people with depressive syndrome respond to TMS treatment.

  Recruiting Goethe University · Frankfurt am Main, Hesse · NCT07422844

• At‑home tDCS maintenance for depression

  This pilot tests whether an at-home transcranial direct current stimulation (tDCS) program can help adults with depression maintain improvements achieved during inpatient treatment.

  Recruiting Technical University of Munich · München, Bavaria and 1 other locations · NCT07269964

• Evaluating LV232 Capsules for Treating Major Depressive Disorder

  This study is testing different doses of LV232 capsules to see if they can help people with major depressive disorder feel better compared to a placebo and an active medication.

  Recruiting Phase 2 Vigonvita Life Sciences · Shanghai · NCT06828887

• Testing Rosuvastatin for treating Major Depressive Disorder

  This study is testing if taking Rosuvastatin can help adults aged 20 to 45 with Major Depressive Disorder feel better over three months.

  Recruiting Phase 3 Ain Shams University · Cairo, Al Abbasia · NCT06698666

• Using psilocybin to treat depression in cancer patients

  This study is testing whether a single dose of psilocybin can help cancer patients with depression feel better compared to a lower dose.

  Recruiting at 4 sites Phase 2 Section for Affective Disorders; Northern Stockholm Psychiatry · Gothenburg, Göteborg and 3 other locations · NCT06319378

• Combining psilocybin with accelerated rTMS for treatment-resistant depression

  This will test whether a single psilocybin dosing session followed by a short, intensive accelerated rTMS course helps adults with treatment-resistant major depressive disorder.

  Recruiting Phase 2 University of Texas at Austin · Austin, Texas · NCT06132178

• Investigating stress and inflammation in women with major depressive disorder and premenstrual dysphoric disorder

  This study is testing how stress and inflammation affect women with major depressive disorder and premenstrual dysphoric disorder during different times in their menstrual cycle to help find better treatments.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT06130371

• Identifying biomarkers for depression and suicide in adolescents

  This study is trying to find specific markers in the body that can help understand depression and suicidal thoughts in teenagers, while also looking at how standard treatments affect these issues.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05437588

Related topics

Quick answers

How many MDD clinical trials are recruiting right now?

12, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in Germany (4 trials), United States (3 trials), Taiwan (1 trial), Brazil (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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