Condition
Severe Depression clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Severe Depression clinical trials that are recruiting, at sites in 2 countries (most in Germany (2), United States (1)). 1 was first registered in the last 30 days. By phase: Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1New in 30 days
- 2Countries
Newest Severe Depression clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Sensation Seeking and TMS Response in TRD: Does Personality Shape Treatment Outcomes? | — | München, Bavaria | Recruiting | Oct 22, 2026 |
| At‑home tDCS maintenance for depression | — | München, Bavaria and 1 other locations | Recruiting | Dec 8, 2025 |
| Nebulized ketamine treatment for major depression in hospitalized patients | Phase 3 | Brooklyn, New York | Recruiting | Dec 31, 2024 |
All recruiting trials (3)
-
Sensation Seeking and TMS Response in TRD: Does Personality Shape Treatment Outcomes?
This real-world study tests whether people with treatment-resistant depression who have higher sensation-seeking traits respond differently to TMS treatment.
-
At‑home tDCS maintenance for depression
This pilot tests whether an at-home transcranial direct current stimulation (tDCS) program can help adults with depression maintain improvements achieved during inpatient treatment.
-
Nebulized ketamine treatment for major depression in hospitalized patients
This study is testing if breathing in ketamine can help people with moderate to severe depression feel better while they are in the hospital.
Related topics
Quick answers
How many Severe Depression clinical trials are recruiting right now?
3, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in Germany (2 trials), United States (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.