Condition

Depression in Adolescence clinical trials and research

• 11Clinical trials
• 2NIH research projects
• 4Countries

Newest Depression in Adolescence clinical trials

All recruiting trials (11)

• Teenthrive 2: Yoga vs. group therapy for teen mood

  A pilot randomized trial tests whether a yoga-based program (YBI) or group cognitive-behavioral therapy (gCBT) helps adolescents with depression at two U.S. sites.

  Recruiting at 2 sites Butler Hospital · Boston, Massachusetts and 1 other locations · NCT07475845

• TAG TEAM: Group CBT for minority stress in trans and gender diverse teens

  This trial tests a group CBT program to help trans and gender diverse adolescents cope with minority stress and improve mood and wellbeing.

  Recruiting Murdoch Childrens Research Institute · Parkville, Victoria · NCT07151079

• Mental health program for at-risk adolescents in Malaysia

  This will test a school-based program called Super Skills for Life against a study-skills control to see if it reduces anxiety and depression and improves wellbeing in 12–14-year-olds from low-income Malaysian communities.

  Recruiting at 5 sites University of Roehampton · Kota Kinabalu, Sabah and 4 other locations · NCT07138664

• Examining how parent-adolescent communication affects mental health treatment outcomes in adolescents

  This study looks at whether better communication between parents and their teenagers can lead to improved mental health treatment results for adolescents over six months.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT06633458

• New treatment for depression in adolescents using brain stimulation

  This study is testing a new brain stimulation treatment for depression in teens aged 14-19 who haven't tried antidepressants before, to see if it helps them feel better.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06523439

• Telehealth program to help teens with depression

  This study tests a telehealth program that helps teens aged 12-17 with depression by teaching them skills to engage in enjoyable activities over eight weeks.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06273995

• Improving sleep to help adolescents with depression

  This study is testing if a new sleep program can help teenagers with depression feel better by improving their sleep schedule.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06139861

• Understanding how sleep affects depression and reward in teenagers

  This study looks at how sleep and stress affect depression and feelings of pleasure in teenagers aged 14-18 to find ways to help prevent these issues.

  Recruiting University of Oregon · Eugene, Oregon · NCT05691439

• Mindfulness and brain feedback for treating depression in teens

  This study is testing a new way to help teens with depression by using mindfulness and brain feedback to see if it can reduce negative thinking and improve their mood.

  Recruiting at 2 sites Columbia University · Boston, Massachusetts and 1 other locations · NCT05617495

• Identifying biomarkers for depression and suicide in adolescents

  This study is trying to find specific markers in the body that can help understand depression and suicidal thoughts in teenagers, while also looking at how standard treatments affect these issues.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05437588

• Investigating inflammation and glutamate in depressed adolescents

  This study is testing how stress affects inflammation and a brain chemical in teenagers with depression to see if these factors can help predict how well they respond to common antidepressants over time.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05329441

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How Sleep Keeps Depression in Check During Teens

  This grant looks at how sleep patterns in teenagers relate to predicting and preventing depression by using big data and deep-learning analyses of adolescent brain and behavior.

  NIH research Stanford University · Stanford, United States · NIH-11167163

• Understanding how reward sensitivity and inflammation contribute to depression in adolescents

  This study is looking at how feeling less excited about rewards and having higher inflammation might be linked to the risk of depression in teens aged 12 to 20, with the goal of finding new ways to help prevent depression during these important years.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11070356

Related topics

Quick answers

How many Depression in Adolescence clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), Australia (1 trial), Malaysia (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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