Testing Rosuvastatin for treating Major Depressive Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the efficacy and safety of Rosuvastatin 10 mg in treating adults with Major Depressive Disorder (MDD). Participants aged 20 to 45 will take the medication daily for three months while attending regular checkups at the Psychiatry Institute of Professor Ahmed Okasha. The study will assess changes in depression severity using the Montgomery Asberg Depression Rating Scale (MADRS) and monitor any side effects experienced by participants. The trial is designed as a randomized controlled trial to ensure robust results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* aged between 20 and 45 years;
* diagnosis of current MDD, verified using the Structured Clinical Interview for DSM-IV Axis I Disorders, patient version (SCID-I/P);
* The Montgomery Asberg Depression Rating Scale (MADRS) score of 7 to 34, indicating mild to moderate depression;
* the ability to give informed consent and to comply with standard procedures;
* Males and females; and
* Stable pharmacological treatment for at least 2 weeks prior to enrolment (changes to medication dose or frequency of therapy excepted) if currently being treated.

Exclusion Criteria:

* lifetime or current SCID-I/P diagnosis of a psychotic disorder;
* lifetime SCID-I/P diagnosis of bipolar I or II disorder or alcohol dependence;
* acute or unstable systemic medical disorder;
* inability to comply with the requirements of informed consent or the study protocol;
* history of intolerance or allergy to study medications;
* Current pregnancy or breast feeding;
* Current regular use of statins, corticosteroids, or any other immunomodulatory agents; and
* Females on Contraception.

Where it's running

• El demerdash hospital
  Cairo, Al Abbasia, Egypt Recruiting

Study contacts

• Study coordinator: Silvana Nader
• Email: Slvana_nader@med.asu.edu.eg
• Phone: 01226058776

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.