Condition

HER2-positive Metastatic Breast Cancer clinical trials and research

• 9Clinical trials
• 8Countries

Newest HER2-positive Metastatic Breast Cancer clinical trials

All recruiting trials (9)

• Dalpiciclib with Anti-HER2 and Endocrine Therapy as Maintenance in HR+/HER2+ Metastatic Breast Cancer

  A phase II trial tests whether adding dalpiciclib to anti-HER2 therapy and endocrine therapy can help advanced HR+/HER2+ breast cancer stay under control after initial treatment.

  Recruiting Phase 2 Sun Yat-sen University · Guangdong, GUANGZHOU · NCT07610720

• Randomising people with HER2‑positive metastatic breast cancer to routine brain MRI surveillance versus no routine surveillance

  This study will test whether people with HER2‑positive metastatic breast cancer can be successfully recruited and randomized to routine brain MRI checks at 6 and 12 months versus usual care with scans only if neurological symptoms develop.

  Recruiting Royal College of Surgeons, Ireland · Beaumont · NCT07503717

• ARX788 in HER2-positive metastatic breast cancer

  This study tests ARX788 every 6 weeks in adults with HER2-positive metastatic breast cancer to see if it helps control tumors.

  Recruiting Phase 2 Henan Cancer Hospital · Zhengzhou, Henan · NCT06663748

• Evaluating BBO-10203 for advanced solid tumors

  This study is testing a new treatment called BBO-10203, alone and with another drug, to see if it can help people with advanced solid tumors, including certain types of breast cancer.

  Recruiting at 43 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Duarte, California and 43 other locations · NCT06625775

• Measuring HER2 levels in metastatic breast cancer patients

  This study is testing a new way to measure HER2 levels in patients with low HER2 metastatic breast cancer to see if it can help identify who will benefit from a specific treatment.

  Recruiting at 37 sites Abramson Cancer Center at Penn Medicine · San Francisco, California and 36 other locations · NCT06551116

• Exploring HER3-DXd treatment for advanced breast cancer

  This study is testing a new treatment called HER3-DXd, both alone and with another drug, to see if it can help people with advanced breast cancer that hasn't responded to previous treatments.

  Recruiting Phase 1/2 Gustave Roussy, Cancer Campus, Grand Paris · Villejuif, France · NCT06298084

• Comparing disitamab vedotin and pyrotinib to standard treatment for HER2-positive advanced breast cancer

  This study is testing a new combination of disitamab vedotin and pyrotinib to see if it works better than the standard treatment for people with newly diagnosed HER2-positive advanced breast cancer.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06278870

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Treatment for breast cancer patients with leptomeningeal disease

  This study is testing a new treatment combining tucatinib, capecitabine, and intrathecal trastuzumab to see if it can help people with HER2-positive metastatic breast cancer and leptomeningeal disease live longer.

  Recruiting at 10 sites Phase 2 Unicancer · Bordeaux and 10 other locations · NCT05800275

Related topics

Quick answers

How many HER2-positive Metastatic Breast Cancer clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in France (3 trials), United States (3 trials), China (3 trials), Ireland (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 2, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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