Condition

Leptomeningeal Disease clinical trials and research

• 8Clinical trials
• 5Countries

Newest Leptomeningeal Disease clinical trials

All recruiting trials (8)

• Dendritic Cell Vaccine with HER2-targeted Therapy or Nivolumab for Breast Cancer with Leptomeningeal Metastasis

  This trial tests a dendritic cell vaccine added to trastuzumab for Her2-positive disease or to nivolumab for Her2-negative disease to see if it can be given safely to people with breast cancer that has spread to the leptomeninges.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT07694986

• Optimizing gadopiclenol MRI to detect early leptomeningeal disease

  This study tests whether using gadopiclenol during brain MRI can improve early detection of leptomeningeal disease in adults with solid cancers.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07415018

• B7-H3 CAR T cells for recurrent brain tumors in kids and young adults

  This early-phase trial tests a personalized CAR T-cell therapy called B7-H3 CAR T for children and young adults with recurrent or progressive brain tumors.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07390539

• Assessment of patients with leptomeningeal metastasis

  This study is trying to create a standard way to check how patients with leptomeningeal metastases are doing, so doctors can better understand and manage their condition.

  Recruiting at 3 sites University of Zurich · Houston, Texas and 2 other locations · NCT06417710

• Register for tracking leptomeningeal disease in Germany

  This study is setting up a database to track how leptomeningeal disease affects patients in Germany, including their treatments and any complications, to better understand the condition.

  Recruiting at 6 sites University Hospital Tuebingen · Bonn and 6 other locations · NCT06146010

• Treatment for breast cancer patients with leptomeningeal disease

  This study is testing a new treatment combining tucatinib, capecitabine, and intrathecal trastuzumab to see if it can help people with HER2-positive metastatic breast cancer and leptomeningeal disease live longer.

  Recruiting at 10 sites Phase 2 Unicancer · Bordeaux and 10 other locations · NCT05800275

• Using PD1 antibody for treating leptomeningeal disease in metastatic solid tumors

  This study is testing if giving a PD1 antibody directly into the spine can help people with leptomeningeal disease from metastatic solid tumors feel better and stay safe.

  Recruiting at 8 sites Phase 1 University Hospital Tuebingen · Bonn and 8 other locations · NCT05112549

• Evaluating high-dose methotrexate for breast cancer with leptomeningeal metastasis

  This study is testing if high-dose methotrexate can help breast cancer patients with leptomeningeal disease feel better and improve their treatment options.

  Recruiting at 2 sites Phase 2 Wake Forest University Health Sciences · Baltimore, Maryland and 2 other locations · NCT02422641

Related topics

Quick answers

How many Leptomeningeal Disease clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (5 trials), Germany (2 trials), France (1 trial), Netherlands (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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