Condition

KRAS G12C clinical trials and research

• 5Clinical trials
• 6Countries

Newest KRAS G12C clinical trials

All recruiting trials (5)

• BBO-11818 treatment for adults with KRAS mutant cancer

  This study is testing a new drug called BBO-11818 to see if it can help adults with certain types of cancer that have specific KRAS mutations.

  Recruiting at 17 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Los Angeles, California and 16 other locations · NCT06917079

• Evaluating BBO-8520 for treating KRAS G12C non-small cell lung cancer

  This study is testing a new drug called BBO-8520 to see if it can safely help adults with a specific type of lung cancer that has a KRAS G12C mutation, both on its own and when combined with another treatment.

  Recruiting at 38 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Birmingham, Alabama and 37 other locations · NCT06343402

• Combining Adagrasib with Stereotactic Radiosurgery for Brain Metastases in Lung Cancer

  This study is testing whether combining a targeted therapy called adagrasib with a type of focused radiation treatment can help people with lung cancer that has spread to the brain feel better.

  Recruiting at 3 sites Phase 2 Hoosier Cancer Research Network · Columbus, Ohio and 2 other locations · NCT06248606

• Evaluating FMC-376 for advanced solid tumors with KRAS G12C mutations

  This study is testing a new drug called FMC-376 to see if it can help people with advanced solid tumors that have a specific KRAS G12C mutation.

  Recruiting at 20 sites Phase 1/2 Frontier Medicines Corporation · La Jolla, California and 25 other locations · NCT06244771

• Targeted therapies for patients with vascular malformations

  This study is testing new targeted treatments for patients with slow-flow and fast-flow vascular malformations to see if they work better than the usual therapies.

  Recruiting at 2 sites Phase 2 Murdoch Childrens Research Institute · Parkville, Victoria and 1 other locations · NCT05983159

Related topics

Quick answers

How many KRAS G12C clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Australia (4 trials), United States (4 trials), South Korea (1 trial), Canada (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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