Condition

HER2-low Breast Cancer clinical trials and research

• 9Clinical trials
• 3Countries

Newest HER2-low Breast Cancer clinical trials

All recruiting trials (9)

• Disitamab vedotin plus bevacizumab for HER2-low metastatic breast cancer after T‑DxD failure

  This study will try disitamab vedotin combined with bevacizumab in adults with HER2‑low metastatic breast cancer whose disease progressed after trastuzumab deruxtecan.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07446452

• Mutant-selective inhibitor CGT6297 in advanced solid tumors with PIK3CA mutations

  This phase 1 study tests CGT6297 to see if it is safe and tolerable, and to get an early sense of activity, in adults with advanced solid tumors that have PIK3CA mutations.

  Recruiting at 12 sites Phase 1 Cogent Biosciences, Inc. · Scottsdale, Arizona and 11 other locations · NCT07383506

• Trastuzumab-rezetecan for HER2-positive and HER2-low breast cancer

  This project will test Trastuzumab-rezetecan in adults with HER2-positive or HER2-low breast cancer who are receiving it as part of routine care to see if it works and is safe.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07358182

• Comparing BL-M07D1 to standard chemotherapy for HER2-low breast cancer

  This study is testing if a new treatment called BL-M07D1 can work better than standard chemotherapy for people with advanced HER2-low breast cancer.

  Recruiting Phase 3 Sichuan Baili Pharmaceutical Co., Ltd. · Guangzhou, Guangdong and 1 other locations · NCT06957886

• Exploring treatment strategies for HER2-low breast cancer using antibody-drug conjugates

  This study looks at how different treatment plans using antibody-drug conjugates can help people with HER2-low breast cancer and what factors might affect their outcomes.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT06877416

• Using HER2-PET imaging to guide HER2-ADC treatment in metastatic HER2-expressing breast cancer

  This trial will test whether HER2-targeted PET imaging can help find people with metastatic HER2-expressing breast cancer who should get the HER2-directed antibody‑drug conjugate T‑DXd.

  Recruiting Karolinska University Hospital · Solna · NCT06830382

• Treatment for HER2-negative metastatic breast cancer using two investigational drugs

  This study is testing if using two new drugs one after the other can help people with HER2-negative metastatic breast cancer live longer and feel better.

  Recruiting at 10 sites Phase 2 Dana-Farber Cancer Institute · Birmingham, Alabama and 10 other locations · NCT06533826

• Assessing Trastuzumab Deruxtecan in Chinese Patients with HER2-positive and HER2-low Breast Cancer

  This study is testing how well Trastuzumab Deruxtecan works for Chinese patients with advanced HER2-positive or HER2-low breast cancer who have already tried other treatments.

  Recruiting at 46 sites Daiichi Sankyo · Beijing and 53 other locations · NCT06210776

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

Related topics

Quick answers

How many HER2-low Breast Cancer clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in China (5 trials), United States (3 trials), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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