Condition

HER2 Gene Mutation clinical trials and research

• 6Clinical trials
• 4Countries

Newest HER2 Gene Mutation clinical trials

All recruiting trials (6)

• Whole-body HER2 PET/CT to see how 89Zr-trastuzumab accumulates in HER2-positive or HER2-mutated advanced NSCLC

  This study tests whether 89Zr-trastuzumab PET/CT can show how much tracer builds up in tumors of adults with HER2-positive or HER2-mutated advanced NSCLC.

  Recruiting Phase 1 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07436858

• HER2 antibody therapy using Lutetium-177 for advanced solid tumors

  This study is testing a new treatment using a special type of radiation for people with advanced solid tumors that are HER2 positive to see if it is safe and effective.

  Recruiting at 5 sites Early Phase 1 Radiopharm Theranostics, Ltd · Kingswood, New South Wales and 4 other locations · NCT06824155

• Investigating genetic similarities between primary colorectal tumors and their brain metastases

  This study is looking at the genetic similarities between original colorectal cancer tumors and their brain metastases to see how closely they match in terms of important gene mutations.

  Recruiting Blokhin's Russian Cancer Research Center · Moscow, Moscow · NCT06449989

• Combining pembrolizumab, trastuzumab, and chemotherapy for HER2+ esophagogastric cancer

  This study is testing if adding pembrolizumab and trastuzumab to standard chemotherapy can help people with resectable HER2+ esophagogastric cancer do better in their treatment.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Boston, Massachusetts and 9 other locations · NCT06123338

• Combining Neratinib and Fam-Trastuzumab Deruxtecan for Advanced Gastro-esophageal Cancer

  This study is testing a new combination of two cancer drugs to see if it can safely help people with advanced gastro-esophageal cancer that has a specific gene change.

  Recruiting at 3 sites Phase 1 Fox Chase Cancer Center · Palo Alto, California and 2 other locations · NCT05274048

• Using T-DM1 with chemotherapy and radiation for HER2-positive salivary gland cancer after surgery

  This study is testing if adding a new drug called T-DM1 to regular chemotherapy and radiation can help people with HER2-positive salivary gland cancer stay cancer-free after surgery.

  Recruiting at 13 sites Phase 2 Dana-Farber Cancer Institute · Atlanta, Georgia and 12 other locations · NCT04620187

Related topics

Quick answers

How many HER2 Gene Mutation clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (3 trials), Russia (1 trial), Netherlands (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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