Drug or treatment

Neratinib clinical trials

• 12Clinical trials
• 4Countries

Newest trials

All recruiting trials (12)

• T-DXd with or without Neratinib for HER2-positive breast cancer with brain metastases

  This trial tests whether adding Neratinib to Trastuzumab Deruxtecan helps treat HER2-positive breast cancer that has spread to the brain.

  Recruiting Phase 2 Fudan University · Shanghai · NCT07152782

• Probiotics to prevent neratinib-related diarrhea in HER2-positive breast cancer patients

  This trial will test whether taking probiotics alongside standard preventive loperamide can reduce diarrhea in people with HER2-positive breast cancer who are starting neratinib compared with placebo.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06892093

• Using Neratinib for Early HER2 Positive Breast Cancer Treatment

  This study is testing if taking neratinib after standard treatments can help people with early HER2 positive breast cancer live longer without the disease coming back.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT06693024

• Testing neratinib alone or with palbociclib for HER2 positive solid tumors

  This study is testing if a new cancer treatment called neratinib works better alone or with another drug, palbociclib, for people with HER2 positive solid tumors, especially those with gynecologic cancers.

  Recruiting at 181 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 193 other locations · NCT06126276

• Combining neratinib and ruxolitinib for treating metastatic triple-negative breast cancer

  This study is testing if combining two medications, neratinib and ruxolitinib, can help people with advanced triple-negative breast cancer who have already been treated with chemotherapy.

  Recruiting Early Phase 1 Baylor Research Institute · Dallas, Texas · NCT06008275

• Using neratinib before surgery for HER2-mutated lobular breast cancers

  This study is testing if adding a new drug called neratinib to standard treatment can help people with HER2-mutated lobular breast cancer before they have surgery.

  Recruiting at 2 sites Phase 2 Vanderbilt-Ingram Cancer Center · Atlanta, Georgia and 4 other locations · NCT05919108

• Treatment for hormone receptor positive HER2 positive breast cancer after neoadjuvant therapy

  This study is testing if combining two drugs, trastuzumab and nelatinib, can help people with hormone receptor positive HER2 positive breast cancer who still have cancer after initial treatment feel better compared to the usual combination of trastuzumab and pertuzumab.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou · NCT05760612

• Using Kadcyla and Neratinib to Treat Early HER2-positive Breast Cancer with Residual Disease

  This study is testing if adding a pill called neratinib to the standard treatment can help people with early HER2-positive breast cancer who still have some cancer cells left after their initial therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT05388149

• Testing a combination of two anti-cancer drugs for HER2-positive solid tumors

  This study is testing a combination of two cancer drugs to see if they can safely help people with advanced HER2-positive solid tumors.

  Recruiting at 15 sites Phase 1 National Cancer Institute (NCI) · Duarte, California and 17 other locations · NCT05372614

• Combining Neratinib and Fam-Trastuzumab Deruxtecan for Advanced Gastro-esophageal Cancer

  This study is testing a new combination of two cancer drugs to see if it can safely help people with advanced gastro-esophageal cancer that has a specific gene change.

  Recruiting at 3 sites Phase 1 Fox Chase Cancer Center · Palo Alto, California and 2 other locations · NCT05274048

• Neratinib and Capecitabine for HER2-Negative Breast Cancer with Brain Metastases

  This study is testing if a combination of neratinib and capecitabine can help people with HER2-negative breast cancer that has spread to the brain.

  Recruiting Phase 2 University of Rochester · Rochester, New York · NCT04965064

• Pre-operative treatment for HER2-positive, ER-positive breast cancer

  This study is testing if a new combination of treatments can help women with HER2-positive, ER-positive breast cancer before they have surgery.

  Recruiting at 4 sites Phase 2 Hoosier Cancer Research Network · Chicago, Illinois and 3 other locations · NCT04886531

Quick answers

How many clinical trials of Neratinib are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (7 trials), China (4 trials), Canada (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 2, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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