Postoperative Low Oxygen and Chance of Leaks After Esophageal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational analysis reviews cases from the past five years to see if postoperative hypoxemia (PaO2 < 80 mmHg) is linked to higher rates of esophageal anastomotic leakage. Patients are categorized by whether they had at least one PaO2 reading below 80 mmHg within the first week after surgery, and leakage rates are compared between groups. The study also explores if correcting hypoxemia could reduce leakage risk, using diagnostic methods such as barium swallow, endoscopy, and imaging to confirm leaks. The goal is to determine whether postoperative hypoxemia is an independent and potentially modifiable risk factor. Findings may inform postoperative care and oxygen management after radical esophagectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with esophageal carcinoma or benign esophageal tumors
* Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction
* Patients must have had at least one postoperative arterial blood gas analysis
* Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram

Exclusion Criteria:

* Patients who did not require esophageal reconstruction
* Patients undergoing esophageal replacement with colon
* Patients with incomplete data

Where it's running

• Department of Thoracic Surgery, Sun Yat-sen University Cancer Center
  Guangzhou, Guangdong, China Recruiting
• Cancer Hospital of Shantou University Medical College
  Shantou, Guangdong, China Recruiting
• The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital
  Shijiazhuang, Hebei, China Recruiting
• Shanghai Chest Hospital
  Shanghai, Shanghai Municipality, China Recruiting
• Sichuan Cancer Hospital
  Chengdu, Sichuan, China Recruiting
• 0817-2598459
  Nanchong, Sichuan, China Recruiting

Study contacts

• Principal investigator: Hong Yang, M.D. — Department of Thoracic Surgery, Sun Yat-sen University Cancer Center
• Study coordinator: Hong Yang, M.D.
• Email: yanghong@sysucc.org.cn
• Phone: 8613560405144

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.