Condition

Cutaneous Squamous Cell Carcinoma (CSCC) clinical trials and research

• 13Clinical trials
• 7Countries

Newest Cutaneous Squamous Cell Carcinoma (CSCC) clinical trials

All recruiting trials (13)

• Seeing if the first lymph node helps detect skin cancer spread earlier

  They are testing whether checking the sentinel lymph node early can help see if high-risk skin squamous cell cancer has started to spread.

  Recruiting Germans Trias i Pujol Hospital · Badalona, Barcelona · NCT07746258

• Long-term real-world follow-up of adults with cutaneous squamous cell carcinoma needing systemic treatment in France

  This study tests how adults with cutaneous squamous cell carcinoma who require systemic therapy are managed in real life, using a national French database across multiple centers.

  Recruiting at 24 sites University Hospital, Lille · Amiens and 28 other locations · NCT07606508

• First-in-human test of KUP-101A in selected advanced skin cancers

  This early study tests KUP-101A to see if it's safe and tolerable and to gather initial clues about its activity in patients with advanced skin cancers.

  Recruiting at 3 sites Phase 1 Kupando GmbH · Munich, Bavaria and 2 other locations · NCT07600476

• Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients

  This trial tests whether applying a 5% niacinamide cream daily, in addition to sunscreen, can reduce actinic keratoses and new skin cancers in adults who have had an organ transplant.

  Recruiting at 2 sites Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania and 1 other locations · NCT07286318

• Next‑generation immune profiling to find response and toxicity markers in skin cancer patients treated with cemiplimab

  This project will test whether advanced blood and tumor immune profiling can help predict who with advanced cutaneous squamous cell carcinoma will benefit from cemiplimab and who may develop side effects.

  Recruiting Instituto de Investigación Biomédica de Salamanca · Salamanca, Salamanca · NCT07064330

• MOHs Surgery and Short-Course Radiation for Head & Neck Skin Cancer

  This study tests whether a short course of radiation after Mohs surgery can prevent recurrence in high-risk cases, and whether some patients with moderate risk can be safely monitored without radiation.

  Recruiting Phase 2 University of Vermont Medical Center · Burlington, Vermont · NCT06998342

• Evaluating the impact of post-operative radiotherapy on high-grade skin cancer

  This study is testing if getting radiation therapy after surgery helps people with high-grade skin cancer live longer and have fewer recurrences compared to those who don't get the treatment.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT06879964

• Using immunotherapy to treat cutaneous squamous cell carcinoma without surgery

  This study is testing if a combination of immunotherapy drugs can help patients with skin cancer avoid surgery.

  Recruiting Phase 2 The Netherlands Cancer Institute · Maastricht, Limburg and 4 other locations · NCT06823479

• Adjuvant radiation versus monitoring after surgery for high-risk cutaneous squamous cell carcinoma

  This compares adding adjuvant radiation after complete surgery to close monitoring to see if people with high-risk cutaneous squamous cell carcinoma stay free of cancer longer.

  Recruiting at 11 sites Phase 3 Centre Leon Berard · Le Puy-en-Velay, Auvergne-Rhône-Alpes and 27 other locations · NCT06692556

• Injecting flu vaccine into skin cancer tumors before surgery

  This study is testing whether injecting the flu vaccine into skin cancer tumors before surgery can help boost the body's immune response against the cancer in people with cutaneous squamous cell carcinoma.

  Recruiting at 2 sites Early Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06664151

• Testing blood samples for cancer DNA in head and neck cancer patients

  This study is testing if checking blood samples for cancer DNA can help predict if head and neck cancer patients will have a relapse after their treatment.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06606028

• Using cemiplimab to treat early-stage skin cancer

  This study tests if injecting a new immune treatment called cemiplimab directly into early-stage skin cancer can work better than regular surgery.

  Recruiting at 50 sites Phase 3 Regeneron Pharmaceuticals · Phoenix, Arizona and 52 other locations · NCT06585410

• Treatment of advanced solid tumors with VET3-TGI immunotherapy

  This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.

  Recruiting at 7 sites Phase 1 KaliVir Immunotherapeutics · Los Angeles, California and 6 other locations · NCT06444815

Related topics

Quick answers

How many Cutaneous Squamous Cell Carcinoma (CSCC) clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (6 trials), France (2 trials), Spain (2 trials), Australia (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Early Phase 1: 2, Phase 2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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