Seeing if the first lymph node helps detect skin cancer spread earlier

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study looks at high-risk cutaneous squamous cell carcinoma and whether proactive examination of the sentinel lymph node can improve outcomes. The study will use lymphadenectomy to remove the sentinel node in participants without evident metastasis. Enrollment targets 142 participants diagnosed with HRcSCC who have no visible spread at baseline. The approach aims to detect spread earlier than imaging or physical exam might reveal. Results could influence how early lymph node assessment is used in managing HRcSCC.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with HRcSCC according to the criteria established in the following table.

Diagnosis of HRcSCC will be made if it complies:

* 3 major criteria
* 2 major criteria and 2 minor criteria
* 1 major criteria and 4 minor criteria.

Major clinical criteria: Major histological criteria:

1. Dystrophic epidermolysis ampollosa
2. Epidermodysplasia verruciforme
3. Congenital dyskeratosis Major tumor thickness of 6 mm.
4. Pigmentose xeroderm
5. Oculocutaneous albinism

   * Immunosuppression by: Perineural invasion Pulmonary transplantation to heart Hematological disease
   * Location: lip, anogenital, atrial pavilion Bone infiltration
   * Tumor recurrence
   * Major tumor diameter of 5 cm.
   * Sign informed consent

Exclusion Criteria:

* \- Presence of clinically obvious metastases (N1)
* Concomitan pathologies with high risk of lethality.
* Concomitan pathologies that contraindicate the test.
* Pregnancy
* Breastfeeding
* T3 or T4 of lip are excluded. These patients will be performed cervical lymphadenectomy by protocol.

Where it's running

• Germans Trias i Pujol Universitary Hospital
  Badalona, Barcelona, Spain Recruiting

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.