Investigating how DNA changes affect heart failure and recovery
Official title: Role of DNA methylation in cardiac failure and recovery
Funded at University of Utah · NIH-10871877 · Data updated 2026-11-12
This study is looking at how changes in DNA might affect heart recovery for people with heart failure who are using special devices to help their hearts pump better, and it invites patients to share their information to help find new ways to improve heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $198,720 |
| NIH project number | 5K23HL150322-05 |
| Project ID | NIH-10871877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with heart failure, particularly those who have been treated with left ventricular assist devices.
✕Less likely to help
Patients with heart failure who are not candidates for LVAD treatment or those with other unrelated cardiac conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of DNA methylation in heart failure and the potential for cardiac recovery. It aims to identify factors that contribute to the recovery of heart function in patients using left ventricular assist devices (LVADs). By combining clinical data with genomic information, the study seeks to uncover the molecular mechanisms behind heart failure and develop predictive models for recovery. Patients may be involved in providing samples and data to help advance this important research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart recovery and improve outcomes for heart failure patients.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and epigenetic factors influencing heart failure recovery, indicating that this approach has potential for success.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Wever-Pinzon, Omar Enrique — University of Utah
- Study coordinator: Wever-Pinzon, Omar Enrique
Related research
Other NIH-funded projects on the same topics.
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Multicenter ECMO for Children: Cardiohelp System
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-
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-
Using the Cardiohelp System for life support in children with severe heart failure
This study is looking at a special heart support device called the Cardiohelp system to see how well it works and keeps kids safe when they have serious heart problems and other treatments haven't worked, and it's for children aged 0 to 16 who need extra help for their hearts.
-
Heart remodeling after endovascular aortic repair
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-
Platelet population changes during ECMO circulatory support
This will test whether the proportions of different platelet types change during ECMO in adults with cardiac or respiratory failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.