Non-invasive brain-computer interface for people with depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing a brain-computer interface (BCI) system to identify neurobiological markers associated with Major Depressive Disorder (MDD). It aims to validate this application by assessing various biological indicators and cognitive states in patients diagnosed with MDD. Participants will undergo comprehensive evaluations, including blood tests and brain imaging, to compare their results with healthy individuals. The study seeks to enhance the understanding of depression and improve treatment methodologies through innovative technology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 12 years old, male or female, right-handed, Han ethnicity
* Meets the DSM-5 diagnostic criteria for depression, with HAMD-17 scores greater than 17 and YMRS scores less than 6;
* Primary school education or above, able to understand the research content, willing to participate in this study and sign an informed consent form

Exclusion Criteria:

* Concomitant or previous history of organic brain disease or severe traumatic brain injury, personal or family history of epilepsy;
* Severe abnormalities in heart, liver, and kidney function;
* Patients with severe physical illnesses;
* History of substance dependence or abuse (alcohol, cocaine, drugs, etc.);
* Patients with mental disorders caused by organic diseases, drug or alcohol induced mental disorders, and other mental disorders;
* Pregnancy or lactation period;
* Within six months, physical therapy such as MECT and TMS should be used;
* Implants of vegetative nerve stimulation;
* Individuals who have implanted electronic or metal instruments (such as pacemakers, defibrillators, stents, orthopedic plates, etc.) and undergo ventriculoperitoneal shunt surgery;
* Obvious visual and auditory impairment, unable to cooperate in completing neuropsychological and scale assessments.

Where it's running

• Shanghai Mental Health Center
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Zhenghui Yi, chief physician
• Email: yizhenghui1971@163.com
• Phone: 18017311007

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sleep-to-Mood in Depression: Home-based tDCS

  This study tests whether home-based tDCS for adults with moderate depression helps sleep improve and whether better sleep is linked to mood improvements.

  Recruiting NYU Langone Health · New York, New York · NCT07572526

• Mindfulness‑augmented brain stimulation for treatment‑resistant depression

  This trial will test whether combining fast brain stimulation (iTBS) with a digital mindfulness program helps people with treatment‑resistant depression reduce symptoms and improve thinking.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT07512284

• Remote Depression Monitoring with Smartphone Data and Alerts

  This study tests whether data from a patient's smartphone can help predict if depressive symptoms will come back after treatment.

  Recruiting at 2 sites Dartmouth-Hitchcock Medical Center · Hanover, New Hampshire and 1 other locations · NCT07174557

• Rapid brain stimulation patterns to boost mood in adults with major depressive disorder

  This study tests different non-invasive brain stimulation patterns to see if they improve mood for adults with major depressive disorder, and how these patterns work with antidepressant treatments.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06976840

• One dose of CYB003 for depression and anxiety

  This study tests whether a single dose of CYB003, a psilocin-related compound, can help symptoms in adults with major depressive disorder and anxiety compared to a placebo.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06820723

• New treatment for depression in adolescents using brain stimulation

  This study is testing a new brain stimulation treatment for depression in teens aged 14-19 who haven't tried antidepressants before, to see if it helps them feel better.

  Recruiting University of Texas at Austin · Austin, Texas · NCT06523439

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.