Combining locoregional therapy with Bevacizumab and PD1/L1 inhibitors for advanced liver cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the efficacy and safety of locoregional therapy combined with Bevacizumab and PD1/L1 inhibitors in patients with advanced hepatocellular carcinoma (HCC) who are not candidates for radical therapy. It will create a comprehensive database to track clinical parameters and outcomes of patients receiving this combination treatment. The study focuses on patients diagnosed with HCC at various stages and aims to provide insights into the management of this condition using a real-world approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. HCC diagnosed by histopathological examination or Guidelines for Diagnosis and Treatment of Primary Liver Cancer or the recurrent HCC after surgery;
2. age between 18 and 75 years;
3. Stage B (middle stage) or C (late stage) HCC determined in accordance with Barcelona Clinic Liver Cancer staging system (BCLC stage).
4. Locoregional therapy include TACE or HAIC, locoregional combined with Bevacizumab and PD1/L1 inhibitor as firstline therapy; non-firstline therapy (previous use of any systemic therapy but intolerant or drug resistant).
5. Child-Pugh class A or B;
6. Eastern Cooperative Group performance status (ECOG) score of 0-2;
7. Hemoglobin ≥ 8.5 g/dL Total bilirubin ≤ 30mmol/L Serum albumin ≥ 32 g/L ASL and AST ≤ 5 x upper limit of normal Serum creatinine ≤ 1.5 x upper limit of normal INR ≤ 1.5 or PT/APTT within normal limits Absolute neutrophil count (ANC) \>1,500/mm3
8. Prothrombin time ≤18s or international normalized ratio \< 1.7.
9. Ability to understand the protocol and to agree to and sign a written informed consent document.

Exclusion Criteria:

1. Cholangiocellular carcinoma (ICC).
2. Patients without image information should be excluded;
3. The survival or patients less than 3 months.
4. Serious medical comorbidities.
5. Evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy.
6. Known history of HIV.
7. History of organ allograft.
8. Known or suspected allergy to the investigational agents or any agent given in association with this trial.
9. Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy.
10. Evidence of bleeding diathesis.
11. Patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry.

Where it's running

• Chinese PLA hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Feng duan, MD — Chinese PLA General Hospital
• Study coordinator: Qunfang Zhou, MD
• Email: zhouqun988509@163.com
• Phone: 86 19868000115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Combining dTACE-HAIC with Bevacizumab and Atezolizumab for treating large liver cancer

  This study is testing a new combination treatment for people with large liver cancer to see if it works better than current options for those who can't have surgery.

  Recruiting Sun Yat-sen University · Beijing, None Selected · NCT06609863

• Targeted FSRT plus bevacizumab versus hippocampus-sparing whole-brain radiation for people with lung adenocarcinoma that has spread to the brain

  This will test whether focused 5-day fractionated stereotactic radiotherapy (FSRT) combined with bevacizumab works better than hippocampus-avoidant whole-brain radiotherapy with a simultaneous boost at controlling brain metastases and protecting memory in adults with lung adenocarcinoma and extensive brain metastases.

  Recruiting at 3 sites Phase 3 Sun Yat-sen University · Chongqing, Chongqing Municipality and 2 other locations · NCT07481786

• QL1706 with bevacizumab plus RALOX-HAIC for liver cancer with VP3/4 portal vein tumor thrombus

  This trial will test whether giving QL1706 together with bevacizumab and RALOX hepatic arterial infusion chemotherapy helps people with hepatocellular carcinoma and VP3/4 portal vein tumor thrombosis live longer or shrink tumors.

  Recruiting Phase 2 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07327788

• Low-dose trifluridine/tipiracil plus bevacizumab for metastatic colorectal cancer

  This will try a lower-dose trifluridine/tipiracil plus bevacizumab regimen for people with metastatic colorectal cancer who have progressed after at least two prior treatments.

  Recruiting at 2 sites Phase 2 Ruijin Hospital · Sanming and 1 other locations · NCT07085169

• BL-B01D1 plus lenvatinib for advanced hepatocellular carcinoma

  This trial tests whether adding BL-B01D1 to lenvatinib helps people with advanced hepatocellular carcinoma shrink tumors or slow disease progression.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06986785

• Combining Befotertinib with Bevacizumab or Chemotherapy for Lung Cancer Treatment

  This study is testing if a new lung cancer treatment combining befotertinib with either bevacizumab or chemotherapy can help patients with early-stage cancer that has an EGFR mutation feel better before surgery.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT06755684

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.