Treatment for advanced liver cancer using new drug combinations

A Randomized, Controlled, Open-label, Multicenter Phase III Clinical Study of Anti CTLA-4 Antibody SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab or Atezolizumab Combined With Bevacizumab for the First-line Treatment of Advanced Hepatocellular Carcinoma

This study is testing whether a new combination of drugs can help people with advanced liver cancer live longer and feel better compared to another treatment option.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 590 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd. (Industry-sponsored)
• Drugs / interventions: Adebrelimab, Bevacizumab, Sintilimab, Atezolizumab
• Locations: 1 site (Hefei, Anhui)
• Trial ID: NCT06618664 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of SHR-8068 combined with Adebrelimab and Bevacizumab compared to Sintilimab combined with Bevacizumab for patients with advanced hepatocellular carcinoma (HCC). It aims to determine which combination provides better outcomes as a first-line treatment for this aggressive form of liver cancer. Participants must have unresectable locally advanced or metastatic HCC and meet specific health criteria. The study will assess the efficacy based on measurable lesions and overall patient survival.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with unresectable advanced HCC who have not received prior systemic therapy.

Not a fit: Patients with other types of liver cancer or those with severe allergic reactions to monoclonal antibodies may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective treatment option for patients with advanced hepatocellular carcinoma.

How similar studies have performed: Other studies have shown promise with similar drug combinations in treating advanced liver cancer, indicating potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

1. Able and willing to provide a written informed consent.
2. ≥ 18 years old, both male and female.
3. Unresectable locally advanced or metastatic HCC confirmed by histopathologically/cytologically.
4. At least one measurable lesion based on RECIST v1.1 criteria.
5. Barcelona clinic liver cancer: Stage B or C.
6. No previous systemic antitumor therapy for HCC.
7. ECOG PS of 0-1.
8. Child-Pugh score of A or B7.
9. Expected survival period ≥ 12 weeks.
10. Adequate organ function.
11. Blood pregnancy negative (women of childbearing age) and non-breastfeeding, effective contraception.

Exclusion Criteria:

1. Hepatic cholangiocarcinoma, mixed hepatocellular carcinoma -cholangiocarcinoma, sarcomatoid hepatocellular carcinoma and fibrolamellar hepatocellular carcinoma.
2. Patients with other malignancies currently or within the past 5 years.
3. With known severe allergic reactions to any other monoclonal antibodies.
4. Patients with known CNS metastasis or hepatic encephalopathy.
5. Patients with liver tumor burden greater than 50% of total liver in volume or received liver transplants.
6. Patients with symptomatic ascites or pleural effusion.
7. Patients with hypertension which cannot be well controlled by antihypertensives.
8. Uncontrolled cardiac diseases or symptoms.
9. Known hereditary or acquired bleeding (e.g., coagulopathy) or a tendency to clot (e.g., hemophiliacs).
10. Major vascular disease occurred in the 6 months before randomization.
11. Gastrointestinal perforation or gastrointestinal fistula within 6 months before randomization.
12. Major surgery within 28 days before randomization or expected to require major surgery during the study period.
13. Active infection, or fever of unknown cause ≥ 38.5℃ in the first 7 days of randomization, or WBC \> 15×109/L at baseline.
14. Known positive history of human immunodeficiency virus test or acquired immunodeficiency syndrome, known HBV infection, known HCV infection.
15. Patients who received live vaccines within 28 days before randomization, or are expected to be vaccinated during the treatment period
16. Patients with other potential factors that may affect the study results.

Where this trial is running

Hefei, Anhui

• Anhui Provincial Hospital — Hefei, Anhui, China (Recruiting)

Study contacts

• Study coordinator: Xin Shi

Conditions Advanced Hepatocellular Carcinoma