Women with chest pain and non-obstructive arteries: personalized diagnostic and treatment approach

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this single-center study, women with angina and non-obstructive coronary arteries undergo an invasive assessment that combines physiology testing, acetylcholine provocation, and intracoronary imaging to identify the dominant mechanism of angina. Based on the phenotype identified, participants receive individualized pharmacologic and lifestyle therapies, with psycho-emotional support as needed. Follow-up visits at 1, 6, and 12 months monitor angina symptoms, quality of life, exercise capacity, treatment adherence, and cardiovascular events. The goal is to establish a structured diagnostic and therapeutic pathway for ANOCA and related conditions at a Uruguayan academic center.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged 35 to 75 years.
* Symptoms compatible with stable angina or suspected myocardial ischemia.
* Non-obstructive coronary arteries, defined as absence of angiographic stenosis greater than or equal to 50%.
* Ability to undergo invasive coronary assessment and clinical follow-up.
* Written informed consent.

Exclusion Criteria:

* Significant structural heart disease.
* Severe left ventricular systolic dysfunction, defined as left ventricular ejection fraction \<40%.
* Clinically relevant contraindication to adenosine or acetylcholine, including severe asthma, untreated high-grade atrioventricular block, or known hypersensitivity.
* Active oncological disease or life expectancy less than 12 months.
* Inability to complete the diagnostic or therapeutic study protocol.
* Participation in another clinical study that could interfere with the present protocol.

Where it's running

• Hospital de Clínicas Dr. Manuel Quintela
  Montevideo, Montevideo Department, Uruguay Recruiting

Study contacts

• Study coordinator: Rafael Mila, MD
• Email: r1000a@gmail.com
• Phone: +59824871515

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.