Stratified medicine approach for managing angina without obstructive coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled trial aimed at improving the management of patients with angina who do not have obstructive coronary artery disease. It evaluates whether tailored medical therapy, guided by an interventional diagnostic procedure during invasive coronary angiography, can enhance patient symptoms, wellbeing, and clinical outcomes. The study builds on previous findings that suggest stratified medicine may significantly benefit patients with microvascular angina and related conditions. Participants will be randomly assigned to receive either the results of the diagnostic procedure or a sham intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years.
2. A clinical plan for invasive coronary angiography.
3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
4. Able to comply with study procedures.
5. Able to provide informed consent.

Exclusion Criteria:

1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
2. History of coronary artery bypass surgery.
3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
4. Logistical reason\*. \*These patients will enter a follow-up registry.

Where it's running

• Radboud University Medical Centre
  Nijmegen, Netherlands Recruiting
• 5th Military Hospital
  Krakow, Poland Recruiting
• Golden Jubilee National Hospital
  Clydebank, Scotland, United Kingdom Recruiting
• William Harvey Hospital
  Ashford, United Kingdom Recruiting
• Bedford Hospital NHS Trust
  Bedford, United Kingdom Recruiting
• Royal Victoria Hospital
  Belfast, United Kingdom Recruiting

Study contacts

• Study coordinator: Colin Berry, MBChB, PhD
• Email: colin.berry@glasgow.ac.uk
• Phone: +44 141 330 3325

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.