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Stratified medicine approach for managing angina without obstructive coronary artery disease

International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry

Not applicable Interventional NHS Greater Glasgow and Clyde · NCT04674449

This study is testing if a personalized treatment plan based on a special heart test can help people with angina who don’t have blocked arteries feel better and improve their health.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1500 (estimated)
Ages18 Years and up
SexAll
SponsorNHS Greater Glasgow and Clyde Academic / other
Locations39 sites (Cork and 38 other locations)
Trial IDNCT04674449 on ClinicalTrials.gov

What this trial studies

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled trial aimed at improving the management of patients with angina who do not have obstructive coronary artery disease. It evaluates whether tailored medical therapy, guided by an interventional diagnostic procedure during invasive coronary angiography, can enhance patient symptoms, wellbeing, and clinical outcomes. The study builds on previous findings that suggest stratified medicine may significantly benefit patients with microvascular angina and related conditions. Participants will be randomly assigned to receive either the results of the diagnostic procedure or a sham intervention.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who are scheduled for invasive coronary angiography and exhibit symptoms of angina.

Not a fit: Patients with obstructive coronary artery disease or those undergoing angiography for non-coronary reasons may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved symptom management and quality of life for patients with microvascular angina.

How similar studies have performed: Previous studies, such as the CorMicA pilot, have shown promising results for similar stratified medicine approaches in managing ischaemic heart disease.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age ≥18 years.
2. A clinical plan for invasive coronary angiography.
3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
4. Able to comply with study procedures.
5. Able to provide informed consent.

Exclusion Criteria:

1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
2. History of coronary artery bypass surgery.
3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
4. Logistical reason\*. \*These patients will enter a follow-up registry.

Where this trial is running

Cork and 38 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Microvascular AnginaAngina, StableIschemia With No Obstructive Coronary ArteriesCoronary Microvascular DysfunctionIschaemic Heart DiseaseNon-Obstructive Coronary AtherosclerosisCoronary Artery DiseaseVasospastic Angina
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.