Using dexmedetomidine during surgery for brain aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of intraoperative dexmedetomidine infusion during endovascular interventions for patients with aneurysmal subarachnoid hemorrhage. Aneurysmal subarachnoid hemorrhage is a critical condition that can lead to severe neurological complications, primarily due to cerebral vasospasm. Dexmedetomidine, a selective α-2 adrenergic receptor agonist, is investigated for its neuroprotective properties and ability to improve cerebral perfusion and reduce cellular injury. The study compares the outcomes of patients receiving dexmedetomidine versus a placebo during their surgical procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged \>18 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) I-III
* Unruptured subarachnoid hemorrhage (SAH) confirmed by digital subtraction catheter angiography (DSA) undergoing endovascular intervention with general anesthesia.

Exclusion Criteria:

* Subarachnoid hemorrhage (SAH) from a lesion other than a ruptured saccular aneurysm.
* Intraventricular or intracerebral blood in the absence of localized thick or diffuse Subarachnoid hemorrhage (SAH).
* No or localized thin subarachnoid hemorrhage (SAH) on computed tomography (CT).
* Cerebral vasospasm on admission digital subtraction catheter angiography (DSA).
* Hypotension (systolic blood pressure 90 mm Hg) refractory to fluid therapy.
* Neurogenic pulmonary edema.
* Cardiac failure requiring inotropic support.
* Severe or unstable concomitant condition or disease or chronic condition.
* Kidney and/or liver disease.
* Prior cerebral damage on computed tomography (CT) scan such as stroke (\>2 cm maximum diameter).
* Pregnancy.
* Traumatic brain injury.
* Previously treated cerebral aneurysm.
* Arterial venous malformation.
* Pre-existing cerebrovascular disorder that will affect diagnosis and evaluation of Subarachnoid hemorrhage (SAH).
* Ischemic heart disease or second or third-degree atrioventricular block.
* Long-term abuse of alcohol, opioids, or sedative-hypnotic drugs.
* Obesity (body mass index \[BMI\] \>30 kg/m2).

Where it's running

• Tanta University Hospitals
  Tanta, ElGharbia, Egypt Recruiting

Study contacts

• Study coordinator: Mohammed S Elsharkawy, MD
• Email: mselsharkawy@med.tanta.edu.eg
• Phone: 00201148207870

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.