Understanding antibiotic resistance and microbiome changes in STI prevention

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the risk of antibiotic resistance and alterations in the human microbiome associated with the use of doxycycline for STI prophylaxis among men who have sex with men (MSM). The study will recruit 108 participants, both users and non-users of STI prophylaxis, who will provide throat swabs and stool samples every six months. These samples will be analyzed for bacterial DNA to identify species present and assess antibiotic resistance. Additionally, participants will complete questionnaires to evaluate the acceptability of the prophylaxis approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥ 18 years.
* Identifies as a man (cis or trans).
* Has sex with men.
* Able to provide informed consent.

Exclusion Criteria:

* Use of an antibiotic other than doxycycline in the 3 months prior to enrolment
* Currently being treated for an STI with doxycycline
* Use of doxycycline within the prior 3 months for an indication other than STI treatment or STI prevention.

Where it's running

• Central and North West London NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Manik Kohli, MBChB MSc
• Email: m.kohli@ucl.ac.uk
• Phone: +4420276794466

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.