Piperacillin Prophylaxis in Major Liver and Pancreatic Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the perioperative pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in adults undergoing major hepatic or pancreatic surgery. It focuses on whether standard dosing achieves target drug exposure despite the physiological changes that occur during these operations. The goal is to understand how factors like fluid shifts and hypoalbuminemia affect antibiotic levels during the perioperative period. Data will help determine if current prophylaxis regimens meet PK/PD targets in high-risk surgical patients. No interventional treatment changes are prescribed within the study protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults \> or = to 18 years old
* Scheduled for major hepatic or pancreatic surgery
* Receiving piperacillin/tazobactam as perioperative antibiotic prophylaxis according to guidelines

Exclusion Criteria:

* decline to participate
* Known allergy of beta-lactam

Where it's running

• CHRU de NANCY
  Nancy, France Recruiting
• CHRU de Nancy
  Vandœuvre-lès-Nancy, Lorraine, France Not yet recruiting

Study contacts

• Study coordinator: Emmanuel NOVY, MD, PhD
• Email: e.novy@chru-nancy.fr
• Phone: +33 383157437

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.