Which single-dose antibiotic works best to prevent complications after lower wisdom tooth removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional study compares three single-dose antibiotics—amoxicillin, clindamycin, and azithromycin—to see which one most effectively reduces post-operative complications after lower third molar extraction. Eligible participants receive one pre-procedure dose, with follow-up assessments on the same day and on day three to measure pain, mouth opening, and bleeding. Data will be analyzed using SPSS to determine which drug provides the best outcomes. The study is conducted at a single institution in Karachi, led by Dow University of Health Sciences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals with no history antibiotics for past 1 month
* No active infection going
* No allergies to any antibiotics, analgesics, local anesthetic
* Cases of low to medium difficulty
* Age bracket from 18 years or older

Exclusion Criteria:

* Pregnant women
* Lactating mothers
* People who have any soft tissue healing disorder
* Patient undergone radiotherapy
* Patient having kidney or liver disease

Where it's running

• Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Principal investigator: Meer M Fawad, Masters of Science — Down University of Health Sciences
• Study coordinator: Meer M Fawad, Masters of Science
• Email: fawadshaikh55@gmail.com
• Phone: +923331255251

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.