Cefazolin Prophylaxis and CSF Levels in Ventricular Shunt Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will measure cefazolin concentration in cerebrospinal fluid after a standard 2 g prophylactic dose given to adults undergoing ventricular shunt placement. The goal is to see if CSF levels are adequate to prevent infection of the valve. They will compare observed concentrations with existing pharmacokinetic models and explore factors that might explain any differences. The study is conducted at Hôpitaux Universitaires de Strasbourg and involves only patients planned for shunt surgery without active infection or allergy to cefazolin.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age \>18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.

Exclusion Criteria:

* Age \<18 years old
* Pregnant women
* Infected patients
* Known cefazolin allergy
* Other molecule used for the antibiotic prophylaxis
* Guardianship or conservatorship
* Patients under curative antibiotherapy
* Non sterile pre operative CSF
* Refusal to participate

Where it's running

• Hôpitaux Universitaires de Strasbourg
  Strasbourg, France Recruiting

Study contacts

• Study coordinator: Baptiste BOUCHIER, MD
• Email: baptiste.bouchier@chru-strasbourg.fr
• Phone: 03.88.12.70.81

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.