Combining Dextran 40 with Ringer's Lactate for treating Acute Pancreatitis
A Randomized Controlled Trial Evaluating Fluid Resuscitation in Acute Pancreatitis: Dextran 40 and Ringer's Lactate (1:3 Ratio) Versus Ringer's Lactate Alone
This study is testing if combining Dextran 40 with Ringer's lactate can help people with mild to moderate acute pancreatitis recover better and avoid serious complications compared to using Ringer's lactate alone.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Satu Mare County Emergency Hospital Government |
| Locations | 1 site (Satu Mare, Satu Mare County) |
| Trial ID | NCT06835023 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates whether a combination of Dextran 40 and Ringer's lactate solution can enhance fluid resuscitation in patients with mild to moderate acute pancreatitis. The study aims to determine if this combination improves patient outcomes by reducing inflammation, organ failure, and the need for intensive care unit admission compared to Ringer's lactate alone. Participants will be randomly assigned to receive either the combination treatment or Ringer's lactate alone, with regular monitoring of their condition and blood tests to assess inflammation and organ function. The goal is to identify the most effective fluid resuscitation strategy for this condition.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with mild or moderate acute pancreatitis.
Not a fit: Patients with severe acute pancreatitis or those who cannot provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved recovery and reduced complications for patients with acute pancreatitis.
How similar studies have performed: While fluid resuscitation is a critical aspect of managing acute pancreatitis, this specific combination approach is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adults (≥18 years) diagnosed with mild or moderate acute pancreatitis * must provide written informed consent for study participation. Exclusion Criteria: * patients who decline to provide informed consent. * patients are non-compliant with treatment and follow-up visits. * pregnant individuals. * patients requiring concomitant treatment that is contraindicated within the study protocol. * patients who develop conditions that contraindicate the administration of the investigational medication. * patients experiencing severe adverse reactions necessitating treatment discontinuation.
Where this trial is running
Satu Mare, Satu Mare County
- Spitalul Judetean de Urgenta Satu Mare — Satu Mare, Satu Mare County, Romania (Recruiting)
Study contacts
- Study coordinator: Costea Cristian PHD STUDENT, MEDICNE
- Email: drcostecristian@gmail.com
- Phone: +40755874293
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.