Combining Dextran 40 with Ringer's Lactate for treating Acute Pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether a combination of Dextran 40 and Ringer's lactate solution can enhance fluid resuscitation in patients with mild to moderate acute pancreatitis. The study aims to determine if this combination improves patient outcomes by reducing inflammation, organ failure, and the need for intensive care unit admission compared to Ringer's lactate alone. Participants will be randomly assigned to receive either the combination treatment or Ringer's lactate alone, with regular monitoring of their condition and blood tests to assess inflammation and organ function. The goal is to identify the most effective fluid resuscitation strategy for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adults (≥18 years) diagnosed with mild or moderate acute pancreatitis
* must provide written informed consent for study participation.

Exclusion Criteria:

* patients who decline to provide informed consent.
* patients are non-compliant with treatment and follow-up visits.
* pregnant individuals.
* patients requiring concomitant treatment that is contraindicated within the study protocol.
* patients who develop conditions that contraindicate the administration of the investigational medication.
* patients experiencing severe adverse reactions necessitating treatment discontinuation.

Where it's running

• Spitalul Judetean de Urgenta Satu Mare
  Satu Mare, Satu Mare County, Romania Recruiting

Study contacts

• Study coordinator: Costea Cristian PHD STUDENT, MEDICNE
• Email: drcostecristian@gmail.com
• Phone: +40755874293

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stroke Volume–Based Fluid Resuscitation in Acute Pancreatitis

  This trial tests whether adjusting IV fluids based on each patient’s stroke volume helps people with acute pancreatitis avoid fluid overload while staying well hydrated.

  Recruiting University of Southern California · Los Angeles, California and 1 other locations · NCT07756476

• Early Upper GI Endoscopy in Acute Pancreatitis (ENDOPAN) - an observational study

  This study tests whether early endoscopic findings in adults with acute pancreatitis relate to how severe their illness becomes.

  Recruiting Jan Kochanowski University · Kielce · NCT07714850

• Carotid ultrasound versus heart echo to guide fluids in septic shock

  This study will test whether carotid artery Doppler flow or left ventricular end-diastolic measurements from echocardiography better predict which adults with septic shock will respond to a fluid bolus.

  Recruiting Ain Shams University · Cairo · NCT07550400

• Acute pancreatitis after percutaneous mechanical thrombectomy: a retrospective analysis

  This project will look at adult medical records to see how often acute pancreatitis happens after percutaneous mechanical thrombectomy for thrombotic peripheral vascular disease.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT07450898

• AI-guided decision support for managing pancreatic conditions

  This project will test an AI tool that reads contrast-enhanced CT scans to help doctors decide whether people with suspected pancreatic disease need surgery, close monitoring, or routine follow-up.

  Recruiting Changhai Hospital · Shanghai · NCT07439757

• Nasojejunal versus oral feeding after endoscopic drainage of walled-off pancreatic necrosis

  This will see if feeding through a tube into the small intestine (nasojejunal feeding) works better than eating by mouth for adults undergoing endoscopic drainage of walled-off pancreatic necrosis.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT07395778

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.