Nasojejunal versus oral feeding after endoscopic drainage of walled-off pancreatic necrosis
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis: A Randomized Controlled Pilot Study
This will see if feeding through a tube into the small intestine (nasojejunal feeding) works better than eating by mouth for adults undergoing endoscopic drainage of walled-off pancreatic necrosis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Post Graduate Institute of Medical Education and Research, Chandigarh Academic / other |
| Locations | 1 site (Chandigarh) |
| Trial ID | NCT07395778 on ClinicalTrials.gov |
What this trial studies
This single-center randomized trial at PGIMER Chandigarh compares nasojejunal tube feeding to oral feeding following endoscopic ultrasonography-guided cystogastrostomy for symptomatic walled-off pancreatic necrosis. Adult patients (18–75 years) who require EUS-guided transluminal drainage and can consent are randomized to one of the two nutritional strategies after the procedure. Key outcomes include infection rates, tube/feed tolerance, weight change, and need for reintervention. Patients with collections not amenable to EUS drainage, major comorbidities, active GI bleeding or obstruction, severe coagulopathy, pregnancy/lactation, or those who are moribund are excluded.
Who should consider this trial
Good fit: Adults aged 18–75 with symptomatic walled-off pancreatic necrosis who require EUS-guided transluminal drainage and can give informed consent are the intended participants.
Not a fit: Patients whose collections are not reachable by EUS, those with active GI bleeding or obstruction, major immunosuppression or malignancy, prior disruptive upper GI surgery, severe coagulopathy, pregnancy/lactation, or those too unstable for endoscopy are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the trial could identify a feeding approach that reduces infections and improves nutritional recovery after endoscopic drainage of walled-off pancreatic necrosis.
How similar studies have performed: Nasojejunal feeding has been used in severe acute pancreatitis and has supportive observational data, but direct randomized evidence specifically comparing nasojejunal versus oral feeding after endoscopic drainage of WON is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients of acute pancreatitis (AP) with 18-75 years of age 2. Patients with symptomatic WON requiring EUS guided transluminal drainage 3. Provision of written informed consent Exclusion Criteria: 1. Patients with collection not amenable for EUS guided drainage (distance of WON \>1 cm from the gastrointestinal lumen) 2. Known malignancy or immunocompromised state 3. Previous upper gastrointestinal(GI) surgery interfering with absorption 4. Active GI bleeding 5. GI obstruction, ileus or persistent vomiting 6. Patients moribund to undergo endoscopic procedure (Glasgow coma scale \<8 or patients on ventilatory support) 7. Patients with irreversible coagulopathy like platelets \<50,000/mm3 and/or INR\>1.5 8. Pregnant or lactating female
Where this trial is running
Chandigarh
- Post Graduate Institute of Medical Education and Research (PGIMER) — Chandigarh, India (Recruiting)
Study contacts
- Principal investigator: Surender Singh Rana, Professor — Post Graduate Institute of Medical Education and Research, Chandigarh
- Study coordinator: Saurabh Kumar Singh
- Email: drsaurabhkrsingh@gmail.com
- Phone: +919560113930
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.