Nasojejunal versus oral feeding after endoscopic drainage of walled-off pancreatic necrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized trial at PGIMER Chandigarh compares nasojejunal tube feeding to oral feeding following endoscopic ultrasonography-guided cystogastrostomy for symptomatic walled-off pancreatic necrosis. Adult patients (18–75 years) who require EUS-guided transluminal drainage and can consent are randomized to one of the two nutritional strategies after the procedure. Key outcomes include infection rates, tube/feed tolerance, weight change, and need for reintervention. Patients with collections not amenable to EUS drainage, major comorbidities, active GI bleeding or obstruction, severe coagulopathy, pregnancy/lactation, or those who are moribund are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients of acute pancreatitis (AP) with 18-75 years of age
2. Patients with symptomatic WON requiring EUS guided transluminal drainage
3. Provision of written informed consent

Exclusion Criteria:

1. Patients with collection not amenable for EUS guided drainage (distance of WON \>1 cm from the gastrointestinal lumen)
2. Known malignancy or immunocompromised state
3. Previous upper gastrointestinal(GI) surgery interfering with absorption
4. Active GI bleeding
5. GI obstruction, ileus or persistent vomiting
6. Patients moribund to undergo endoscopic procedure (Glasgow coma scale \<8 or patients on ventilatory support)
7. Patients with irreversible coagulopathy like platelets \<50,000/mm3 and/or INR\>1.5
8. Pregnant or lactating female

Where it's running

• Post Graduate Institute of Medical Education and Research (PGIMER)
  Chandigarh, India Recruiting

Study contacts

• Principal investigator: Surender Singh Rana, Professor — Post Graduate Institute of Medical Education and Research, Chandigarh
• Study coordinator: Saurabh Kumar Singh
• Email: drsaurabhkrsingh@gmail.com
• Phone: +919560113930

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.