Early Upper GI Endoscopy in Acute Pancreatitis (ENDOPAN) - an observational study

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort enrolls adults with acute pancreatitis diagnosed by the revised Atlanta criteria. Endoscopy is performed within 24–48 hours of hospital admission to document gastric and duodenal mucosal changes, with a possible follow-up procedure before discharge in more severe cases. Researchers will collect clinical, laboratory, imaging, microbiology, and endoscopic data during the hospital stay to explore associations between early mucosal abnormalities and disease severity and clinical course. The goal is to see if early upper GI findings can help predict progression to moderately severe or severe pancreatitis and guide management. No interventional treatment is described; the study is observational and aims to identify potential prognostic markers from endoscopic observations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older.
* Diagnosis of acute pancreatitis according to the revised Atlanta criteria, defined by the presence of at least two of the following three features:

typical abdominal pain consistent with acute pancreatitis; serum amylase and/or lipase activity at least three times the upper limit of normal; imaging findings consistent with acute pancreatitis.

* Hospital admission due to acute pancreatitis to the study center.
* Admission during the early phase of acute pancreatitis, allowing planned upper gastrointestinal endoscopy within 24-48 hours from hospital admission.
* Ability to undergo diagnostic upper gastrointestinal endoscopy according to the investigator's and treating physician's assessment.
* Ability to provide written informed consent before enrollment and before any study-specific procedure.

Exclusion Criteria:

* Age below 18 years.
* Lack of written informed consent.
* Inability to provide informed consent before enrollment.
* Clinical condition precluding safe diagnostic upper gastrointestinal endoscopy, including hemodynamic instability, severe respiratory failure, or other unstable life-threatening condition.
* Need for emergency therapeutic upper gastrointestinal endoscopy before planned study endoscopy, for example due to active upper gastrointestinal bleeding.
* Known or suspected gastrointestinal perforation.
* Previous gastric or duodenal surgery significantly altering upper gastrointestinal anatomy and preventing reliable assessment of gastric or duodenal mucosa.
* Known advanced upper gastrointestinal malignancy affecting the stomach or duodenum.
* Pregnancy.
* Contraindication to upper gastrointestinal endoscopy or sedation according to the treating physician's or investigator's assessment.
* Any condition that, in the investigator's opinion, would make participation unsafe or would prevent completion of study procedures.

Where it's running

• Department of General, Oncologic and Endocrine Surgery, Regional Hospital in Kielce
  Kielce, Poland Recruiting

Study contacts

• Principal investigator: Łukasz Nawacki — Jan Kochanowski University in Kielce, Poland
• Study coordinator: Łukasz Nawacki, PhD habilitated
• Email: lukasz.nawacki@ujk.edu.pl
• Phone: +4841349 69 09

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using bowel sounds to predict severe acute pancreatitis

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• Combining Dextran 40 with Ringer's Lactate for treating Acute Pancreatitis

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.