Using bowel sounds to predict severe acute pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify patients with acute pancreatitis (AP) who are at risk of progressing to severe acute pancreatitis (SAP) by monitoring bowel sounds. Conducted across multiple centers, the study will enroll newly diagnosed AP patients and utilize continuous bowel sound monitoring for at least 48 hours. An automated algorithm will analyze the collected data to create a bowel sound activity index, which will serve as a diagnostic indicator for predicting the occurrence of SAP during hospitalization.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Aged between 18 and 85 years old.
2. Meet the diagnostic criteria for AP, at least two of the following three: (a) characteristic abdominal pain; (b) serum amylase and lipase levels are greater than three times the upper limit of normal; (c) abdominal images with typical manifestations of AP.
3. AP patients within 48 hours of onset.
4. The patient or family members understand the study protocol and sign the informed consent form.

Exclusion criteria:

The patients who fulfill any of the following criteria will be excluded:

1. Patients with serious conditions requiring surgery and abdominal lavage.
2. Pregnant women.
3. The patients with muscle and nerve disorders, chronic pancreatitis, inflammatory bowel disease, cancer, and irritable bowel syndrome.
4. The patients with severe digestive, respiratory, cardiovascular, hematological, endocrine, psychiatric, and infectious diseases.
5. The patients have a history of abdominal surgery (except appendectomy or cholecystectomy).
6. Allergic to silicone, polycarbonate materials or medical plaster. The intake of antibiotic, probiotics, and Chinese herbal medicine will be recorded before the collection of the swabs and will not be considered as exclusion criteria.

Where it's running

• Peking Union Medical College Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Ziying Han, Doctor of Medicine
• Email: hanziying@pumch.cn
• Phone: +86 15811301605

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Stroke Volume–Based Fluid Resuscitation in Acute Pancreatitis

  This trial tests whether adjusting IV fluids based on each patient’s stroke volume helps people with acute pancreatitis avoid fluid overload while staying well hydrated.

  Recruiting University of Southern California · Los Angeles, California and 1 other locations · NCT07756476

• Early Upper GI Endoscopy in Acute Pancreatitis (ENDOPAN) - an observational study

  This study tests whether early endoscopic findings in adults with acute pancreatitis relate to how severe their illness becomes.

  Recruiting Jan Kochanowski University · Kielce · NCT07714850

• Acute pancreatitis after percutaneous mechanical thrombectomy: a retrospective analysis

  This project will look at adult medical records to see how often acute pancreatitis happens after percutaneous mechanical thrombectomy for thrombotic peripheral vascular disease.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT07450898

• AI-guided decision support for managing pancreatic conditions

  This project will test an AI tool that reads contrast-enhanced CT scans to help doctors decide whether people with suspected pancreatic disease need surgery, close monitoring, or routine follow-up.

  Recruiting Changhai Hospital · Shanghai · NCT07439757

• Nasojejunal versus oral feeding after endoscopic drainage of walled-off pancreatic necrosis

  This will see if feeding through a tube into the small intestine (nasojejunal feeding) works better than eating by mouth for adults undergoing endoscopic drainage of walled-off pancreatic necrosis.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT07395778

• Fecal microbiota transplant for people with moderate to severe acute pancreatitis

  This trial will test whether a fecal microbiota transplant (FMT) can reduce late complications in adults with moderate to severe acute pancreatitis.

  Recruiting at 2 sites Changhai Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT07153809

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.