Wireless home prehabilitation for older adults with NSCLC awaiting lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, patients aged 65–85 with NSCLC scheduled for curative lobectomy or segmentectomy receive a home-based prehabilitation program or standard perioperative care. The intervention uses wireless wearables and a smartphone app to monitor steps, heart rate, and oxygen saturation while delivering a tailored mix of aerobic, resistance, and inspiratory muscle exercises for 2–4 weeks before surgery and through 90 days after. Primary outcome is the difference in FEV1 percent predicted at 90 days post-surgery, adjusted for baseline, with several secondary endpoints including functional capacity, daily activity, hypoxemia measures, patient-reported quality of life, dyspnea, postoperative complications, and readmissions. The trial aims to determine safety and feasibility as well as potential improvements in recovery. Enrollment is restricted to older adults with adequate access to and ability to use the monitoring devices and app, under the care of West China Hospital in Chengdu, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥65 and ≤85 years
* Histopathologically confirmed primary non-small cell lung cancer (NSCLC), scheduled for elective curative-intent lobectomy or segmentectomy
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2, or Karnofsky Performance Status (KPS) score ≥70
* Planned admission for surgery within 2 months, and judged by the investigator to have stable disease suitable for participation in a home-based rehabilitation program
* Able to operate a smartphone application and wearable devices independently or with caregiver assistance
* Willing and able to provide written informed consent

Exclusion Criteria:

* Pre-existing long-term home oxygen therapy, or severe resting respiratory dysfunction
* Concurrent severe, uncontrolled cardiovascular disease, hepatic insufficiency, or renal insufficiency
* Other diseases that seriously affect motor function or compliance
* Known or suspected contact allergy to medical adhesives or materials used in the wearable devices
* Any other condition that, in the investigator's judgment, makes the subject unsuitable for participation

Where it's running

• West China Hospital
  Chengdu, Sichuan, China Recruiting

Study contacts

• Study coordinator: Xuelei Ma, MD
• Email: linnan@stu.scu.edu.cn
• Phone: 18708305692

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.