Predicting low blood pressure from spinal anesthesia during cesarean section
Official title: The Value of Waist Circumference, Body Mass Index, and Modified Shock Index in Predicting Spinal Anesthesia-Induced Hypotension During Cesarean Section: A Prospective Observational Study
Run by TC Erciyes University · NCT07499947 · Data updated 2026-11-12
This study will test whether body-shape measures (body roundness index and waist circumference) and simple heart/blood pressure indexes can help predict which full-term women having a cesarean with spinal anesthesia will develop low blood pressure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Months to 45 Months |
| Sex | Women only |
| Enrollment | 321 (estimated) |
| Sponsor | TC Erciyes University Academic / other |
| Locations | 1 site (Kayseri) |
| Status | Recruiting |
| Started | March 16, 2026 |
| Main results expected | October 20, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | March 31, 2026 |
| Trial ID | NCT07499947 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Term (≥37 weeks) pregnant women aged 18–45 with singleton pregnancies, ASA II, attending regular antenatal care and scheduled for elective cesarean under spinal anesthesia were the target participants.
✕Probably not a fit
Patients with preexisting hypertension, significant cardiac or cerebrovascular disease, emergency cesarean, placenta previa/accreta/percreta, bleeding disorders, or on anticoagulants were excluded and are unlikely to benefit from this specific predictive approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study of term parturients undergoing elective cesarean with standardized spinal anesthesia using hyperbaric bupivacaine. Before anesthesia, investigators recorded anthropometric measures (BMI, waist circumference, body roundness index) and hemodynamic indices including the modified shock index; intraoperative blood pressure, heart rate, and sensory block levels were then monitored. Women with hypertension, major cardiovascular or cerebrovascular disease, emergency cesarean, placenta accreta spectrum, or on anticoagulants were excluded. The main aim was to compare whether BRI and waist circumference predict spinal anesthesia–induced hypotension better than conventional markers such as BMI or MSI.
Why it matters
Potential benefit: If successful, the findings could enable clinicians to identify women at higher risk of spinal anesthesia–induced hypotension and tailor preventive measures and monitoring to improve maternal and fetal safety.
How similar studies have gone: Prior observational work has linked MSI and BMI to post-spinal hypotension, but applying body roundness index and waist circumference as predictors is relatively novel and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. American Society of Anesthesiologists (ASA) Class II 2. Having regular antenatal visits 3. Singleton pregnancy at ≥37 weeks of gestation 4. Pregnant women aged 18-45 - Exclusion Criteria: 1. Those with eclampsia, those with preeclampsia 2. Undergoing an emergency cesarean section 3. Those with bleeding diathesis and those receiving anticoagulant therapy 4. With a history of carotid artery stenosis, 5. Cardiovascular disease, 6. Hypertension, 7. Chronic obstructive pulmonary disease, 8. Heart rhythm outside of sinus 9. Patients with a history of cerebrovascular disease 10. Alcoholism or psychiatric illness 11. Placenta previa, accreta, and percreta
Where it's running
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University hospital
Kayseri, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Kudret Doğru, 1 — TC Erciyes University
- Study coordinator: Kudret Dogru, 1
- Email: kdogru@erciyes.edu.tr
- Phone: +905334735112
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.