Dexamethasone versus magnesium added to bupivacaine for erector spinae plane block after elective cesarean

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators will compare the effects of adding either dexamethasone or magnesium sulfate to bupivacaine for bilateral ultrasound-guided erector spinae plane (ESP) blocks in women having elective cesarean delivery under spinal anesthesia. Participants will receive the ESP block with bupivacaine plus one of the adjuvants and postoperative outcomes such as pain scores, duration of analgesia, and opioid consumption will be recorded. The ESP block is an interfascial paraspinal technique intended to provide both somatic and visceral pain relief for Pfannenstiel incisions. The goal is to identify which adjuvant prolongs and improves postoperative analgesia with acceptable safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 35 years.
* Full-term, singleton, pregnant women.
* American Society of Anesthesiologists (ASA) physical status II.
* Scheduled for elective cesarean delivery under spinal anesthesia.

Exclusion Criteria:

* Refusal of the patient.
* Emergency caesarean sections.
* Patients having chronic diseases as asthma, cardiovascular disorders (Significant arrhythmias, Severe Valvular diseases, congenital heart diseases, ischemic heart disease, cardiomyopathy, deep venous thrombosis ,and pulmonary embolism)
* Renal impairment (Creatinine level ≥ 2mg/dl, urea ≥ 25mg/dL), liver impairment \[Alanine aminotransferase (ALT) \< 45 U/L, Aspartate aminotransferase (AST) \< 45 U/L\].
* Allergy to the drug enrolled in the study.
* Body mass index (BMI) ≥ 35 kg/m2.
* Hypertensive disorders of pregnancy.
* Contraindication to spinal anesthesia, such as coagulopathy \[platelet count \<150.000, international normalized ratio (INR) \> 1.2\], or local infection.
* Requirement for conversion to general anesthesia after spinal anesthesia will also be excluded.

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Esraa E Farrag, Master
• Email: esraa.es1@gmail.com
• Phone: 00201229244923

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.