Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Post-Isometric Relaxation and Myofascial Release for Low Back Pain with Lower Cross Syndrome

Official title: Combined Effects of Post-Isometric Relaxation and Myofascial Release in Patients With Low Back Pain and Lower Cross Syndrome: A Randomized Controlled Trial

Run by University of Karachi · NCT07496099 · Data updated 2026-11-12

This trial tests whether combining post-isometric relaxation with myofascial release helps reduce pain and improve flexibility and function for adults with low back pain and lower cross syndrome.

More Low Back Pain trials

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment60 (estimated)
SponsorUniversity of Karachi
Academic / other
Locations1 site (Karachi, Sindh)
StatusRecruiting
StartedAugust 25, 2026
Main results expectedFebruary 5, 2027
Study endsMarch 20, 2027
Registry record updatedAugust 28, 2026
Trial IDNCT07496099 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–45 with at least 4 weeks of low back pain, diagnosed with lower cross syndrome and hamstring tightness (active knee extension >15°).

Probably not a fit

Persons outside the age range, without lower cross syndrome, or without hamstring tightness may not benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will compare two physiotherapy approaches in adults aged 18 to 45 with chronic low back pain and lower cross syndrome. Participants will be randomly assigned to receive either post-isometric relaxation with myofascial release or conventional stretching with therapeutic modalities. Outcomes related to pain, flexibility, and functional disability will be measured at baseline and after the intervention period to determine if the combined techniques provide additional benefit. The study aims to inform evidence-based physiotherapy management for posture-related low back pain. Conducted at Life Cure Physiotherapy Clinic in Karachi with University of Karachi as lead sponsor and IQRA University as collaborator.

Why it matters

Potential benefit: If successful, patients may experience greater pain relief, improved hamstring flexibility, and better overall function.

How similar studies have gone: Previous work in manual therapy approaches for similar conditions has shown mixed but promising results for soft-tissue techniques when combined; this study adds targeted comparison with conventional stretching.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Participants aged 18-45 years old
2. having low back pain persisting for at least 4 weeks
3. with clinical diagnosis of LCS, and hamstring tightness (AKE \>15°)

Exclusion Criteria:

1. Participants with the history of spinal surgery active neurological conditions
2. systemic disease affecting connective tissue (Rheumatoid arthritis, Systemic lupus erythematosus)
3. recent lower limb or spinal injury (within 6 months)
4. pregnancy or inability to lie prone for treatment.

Where it's running

  • life cure physiotherapy clinic malir cantt, Karachi
    Karachi, Sindh, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.