Post-Isometric Relaxation and Myofascial Release for Low Back Pain with Lower Cross Syndrome
Official title: Combined Effects of Post-Isometric Relaxation and Myofascial Release in Patients With Low Back Pain and Lower Cross Syndrome: A Randomized Controlled Trial
Run by University of Karachi · NCT07496099 · Data updated 2026-11-12
This trial tests whether combining post-isometric relaxation with myofascial release helps reduce pain and improve flexibility and function for adults with low back pain and lower cross syndrome.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Karachi Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | August 25, 2026 |
| Main results expected | February 5, 2027 |
| Study ends | March 20, 2027 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT07496099 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–45 with at least 4 weeks of low back pain, diagnosed with lower cross syndrome and hamstring tightness (active knee extension >15°).
✕Probably not a fit
Persons outside the age range, without lower cross syndrome, or without hamstring tightness may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial will compare two physiotherapy approaches in adults aged 18 to 45 with chronic low back pain and lower cross syndrome. Participants will be randomly assigned to receive either post-isometric relaxation with myofascial release or conventional stretching with therapeutic modalities. Outcomes related to pain, flexibility, and functional disability will be measured at baseline and after the intervention period to determine if the combined techniques provide additional benefit. The study aims to inform evidence-based physiotherapy management for posture-related low back pain. Conducted at Life Cure Physiotherapy Clinic in Karachi with University of Karachi as lead sponsor and IQRA University as collaborator.
Why it matters
Potential benefit: If successful, patients may experience greater pain relief, improved hamstring flexibility, and better overall function.
How similar studies have gone: Previous work in manual therapy approaches for similar conditions has shown mixed but promising results for soft-tissue techniques when combined; this study adds targeted comparison with conventional stretching.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Participants aged 18-45 years old 2. having low back pain persisting for at least 4 weeks 3. with clinical diagnosis of LCS, and hamstring tightness (AKE \>15°) Exclusion Criteria: 1. Participants with the history of spinal surgery active neurological conditions 2. systemic disease affecting connective tissue (Rheumatoid arthritis, Systemic lupus erythematosus) 3. recent lower limb or spinal injury (within 6 months) 4. pregnancy or inability to lie prone for treatment.
Where it's running
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life cure physiotherapy clinic malir cantt, Karachi
Karachi, Sindh, Pakistan Recruiting
Study contacts
- Principal investigator: Bushra Madad Ali Malik, DPT — University of Karachi
- Study coordinator: Bushra Madad Ali Malik, MPHIL
- Email: bushramalik0910@gmail.com
- Phone: +92305 2722589
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Autogenic Inhibition vs Reciprocal Inhibition in Lower Crossed Syndrome
This study tests whether two Muscle Energy Technique approaches work differently for people with Lower Crossed Syndrome.
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Acute Effects of Neurodynamics on Hamstrings in Athletes
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Autogenic inhibition versus reciprocal inhibition for lower cross syndrome
This trial tests whether autogenic inhibition or reciprocal inhibition techniques better reduce pain and improve function in adults aged 25–50 with lower cross syndrome.
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Lumbar stabilization exercises versus muscular chain therapy for mechanical chronic low back pain
This trial tests whether lumbar stabilization exercises or muscular chain (posterior sagittal) therapy better reduce pain and disability in people aged 18–30 with mechanical chronic low back pain.
-
Shoulder–pelvis PNF exercises versus suboccipital release for chronic neck pain with tight hamstrings
This project will test whether a shoulder-to-pelvis PNF exercise program helps 18–40-year-olds with chronic neck pain and tight hamstrings more than suboccipital muscle release combined with hamstring stretching.
-
Comparing Jandas Approach and PNF Technique for Lower Cross Syndrome
This study is testing which physical therapy method, Jandas Approach or PNF, works better for helping people with Lower Cross Syndrome feel less pain and improve their movement and quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.