Oliceridine PCIA for Postoperative Pain After VATS Lung Resection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, randomized, double-blind study comparing oliceridine to sufentanil for perioperative pain control in adults undergoing unilateral VATS lung resection. The goal is to see if using oliceridine reduces the development of chronic postsurgical pain with functional impact. Approximately 320 participants will be enrolled across seven tertiary centers in China. Analgesia is delivered via patient-controlled intravenous analgesia, and outcome measures include the incidence and functional consequences of CPSP. The trial is designed to generate evidence on whether oliceridine offers advantages over sufentanil in this surgical context.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-75 years
* ASA physical status I-III
* BMI 18-35 kg/m²
* Scheduled for unilateral video-assisted thoracoscopic surgery (VATS) lung resection, including wedge resection, segmentectomy, lobectomy, or radical resection for lung cancerresection for lung cancer
* Preoperative Numeric Rating Scale (NRS) pain score of 0
* Ability to understand the study objectives and procedures, with voluntary informed consent obtained
* Expected postoperative recovery in the general ward setting

Exclusion Criteria:

* History of chronic pain or long-term analgesic use prior to surgery
* Previous ipsilateral thoracic surgery
* Prior neoadjuvant radiotherapy or chemotherapy
* Severe cardiovascular or cerebrovascular disease, or hepatic/renal dysfunction (ALT/AST \> 3 × upper limit of normal; eGFR \< 60 mL/min/1.73 m²)
* Severe or unstable psychiatric disorders requiring psychoactive medication (e.g., schizophrenia, bipolar disorder), or cognitive impairment precluding reliable self-report
* Other concurrent active malignancy or active infection
* Known hypersensitivity to study medications (opioids, adjuvant analgesics, anesthetics, or antiemetics)
* Pregnancy, lactation, or planned pregnancy during the study period
* Participation in another interventional clinical trial within 3 months before enrolment
* Any condition deemed unsuitable for study participation by the investigator

Where it's running

• The No. 2 Hospital of Baoding
  Baoding, Hebei, China Recruiting
• North China University of Science and Technology Affiliated Hospital
  Tangshan, Hebei, China Recruiting
• Tianjin Medical University General Hospital
  Tianjin, China Recruiting
• Haibin People's Hospital of Tianjin Binhai New Area
  Tianjin, China Recruiting
• The People's Hospital of Jizhou District, Tianjin
  Tianjin, China Recruiting
• The Second Hospital of Tianjin Medical University
  Tianjin, China Recruiting

Study contacts

• Principal investigator: Yang Jiao, Doctor — Tianjin Medical University General Hospital
• Study coordinator: Yang Jiao, Doctor
• Email: jiaoxiuxiu1987@163.com
• Phone: +86 159 0029 2506

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.