Investigating the link between atrophic gastritis and gastric cancer risk
Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study
This study is trying to see if people with atrophic gastritis are more likely to develop gastric cancer, especially in areas where gastric cancer is common.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2042 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06203327 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the incidence of gastric cancer (GC) associated with atrophic gastritis in a region known for high GC rates. It will involve esophagogastroscopy procedures to assess the severity of gastric mucosal atrophy and intestinal metaplasia, which are significant risk factors for developing GC. The study will collect biopsies following the updated Sydney system recommendations to ensure accurate data collection and analysis. By understanding this relationship, the study seeks to provide insights into early detection and prevention strategies for gastric cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 to 80 who have atrophic gastritis and are willing to provide informed consent.
Not a fit: Patients with a history of gastrectomy or severe systemic diseases or malignancies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance early detection and prevention strategies for gastric cancer in at-risk populations.
How similar studies have performed: Previous studies have indicated a strong correlation between atrophic gastritis and gastric cancer, suggesting that this approach is supported by existing literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ability and willingness to participate in the study and to sign and give informed consent * Biopsies were collected based on the recommendation of updated Sydney system Exclusion Criteria: * under 18 or over 80 years old * history of gastrectomy * severe systemic diseases or malignancy
Where this trial is running
Shanghai, Shanghai Municipality
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University — Shanghai, Shanghai Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.