Registry and study on Helicobacter Pylori and related gastric conditions
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
This study is trying to track how Helicobacter pylori infections affect the development of stomach problems, like pre-cancerous changes and cancer, in adults over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 260 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 2 sites (Hong Kong and 1 other locations) |
| Trial ID | NCT05053945 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish a registry to investigate the progression of pre-neoplastic lesions and gastric cancer associated with Helicobacter pylori infection. It will involve longitudinal data collection from adults diagnosed with H. pylori infection, atrophic gastritis, intestinal metaplasia, dysplasia, or gastric cancer. The study will utilize esophagogastroduodenoscopy for surveillance and data gathering to better understand the factors influencing disease progression and optimal surveillance techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with a current or past diagnosis of H. pylori infection and related gastric conditions.
Not a fit: Patients with co-morbid illnesses that prevent endoscopic surveillance or those who decline participation in the study will not benefit.
Why it matters
Potential benefit: If successful, this study could lead to improved surveillance strategies and treatment approaches for patients at risk of gastric cancer.
How similar studies have performed: Other studies have shown success in similar approaches, particularly in countries with high gastric cancer incidence, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults \>= 18 years of age * Written informed consent obtained * Diagnosed with current or past H. pylori infection, * Histologically proven atrophic gastritis (body and/or antrum of stomach), intestinal metaplasia (complete and incomplete), dysplasia (any grade) and/or gastric cancer (post- treatment) Exclusion Criteria: * Co-morbid illness that prohibit endoscopic surveillance * Declines for study questionnaire, biobanking of specimens and/or regular review per study protocol
Where this trial is running
Hong Kong and 1 other locations
- Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
- S.H. Ho Centre for Digestive Health, Prince of Wales Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Andrew Ming Yeung HO
- Email: andrewho@cuhk.edu.hk
- Phone: 26371398
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.