How autoimmune atrophic gastritis develops and presents over time
Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis
This project will follow adults with autoimmune atrophic gastritis to see how the disease progresses and affects the stomach, nutrient absorption, and overall health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Trial ID | NCT07388459 on ClinicalTrials.gov |
What this trial studies
This single-center observational project at Fondazione IRCCS Policlinico San Matteo in Pavia will enroll adults diagnosed with autoimmune atrophic gastritis using the updated Sydney System and obtain written informed consent. Investigators will collect clinical history, histological and laboratory data (including markers of gastric autoimmunity and evidence of nutrient deficiencies) and document changes over time without giving experimental treatment. Patients with uncertain histopathology, active Helicobacter pylori infection, long-term proton pump inhibitor use, or atrophic pangastritis are excluded. The aim is to characterize the natural history, clinical features, and downstream effects of hypo-achlorhydria, including impacts on microbiota and systemic complications.
Who should consider this trial
Good fit: Adults (age ≥18) with a confirmed diagnosis of autoimmune atrophic gastritis per the updated Sydney System who can provide written informed consent and attend the participating tertiary outpatient clinic.
Not a fit: Patients with uncertain histopathology, active H. pylori infection, long-term proton pump inhibitor use, or atrophic pangastritis are excluded and thus unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could improve diagnosis, monitoring, and prevention of complications such as vitamin B12 and iron deficiency in people with autoimmune atrophic gastritis.
How similar studies have performed: Prior research on autoimmune atrophic gastritis is limited and largely cross-sectional, so comprehensive longitudinal natural-history data are sparse.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female, age ≥18 years; * AAG diagnosis is made according to the updated Sydney System criteria referring to a tertiary outpatient clinic dedicated; * Signed written informed consent. Exclusion Criteria: * Patients with uncertain histopathological findings; * Patients with persistent or active Helicobacter pylori infection; * Patients with long-term proton pump inhibitor users and atrophic pangastritis
Where this trial is running
Pavia, Pavia
- Fondazione IRCCS Policlinico San Matteo, SC Medicina Generale 1 — Pavia, Pavia, Italy (Recruiting)
Study contacts
- Study coordinator: Emanuela Miceli, MD
- Email: e.miceli@smatteo.pv.it
- Phone: +390382503545
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.