Monitoring patients with precursors to gastric cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate patients with premalignant gastric conditions, such as atrophic gastritis and intestinal metaplasia, to determine the best methods for their identification and follow-up. It will utilize high-resolution endoscopy and validated histological scales to assess the risk of gastric cancer over time. The study will involve multiple gastroenterology departments across various countries and will focus on patients over 45 years old who are scheduled for upper gastrointestinal endoscopy. By analyzing clinical, histological, and endoscopic factors, the study seeks to establish optimal surveillance protocols for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled for upper GI endoscopy with indication for gastric biopsies, including those with known gastric pathology (e.g. auto-immune gastritis) or premalignant conditions (e.g patients under surveillance because of atrophic gastritis);
* Age above 45 years old

Exclusion Criteria:

* History of previous gastrectomy;
* History of endoscopic resection of neoplastic lesion
* History of previous gastric dysplasia (even with no detectable lesion)
* Hereditary syndromes that increase gastric cancer risk (familial adenomatous polyposis; Lynch syndrome)
* Serious comorbidities (ASA 3 or more)
* Medication with anticoagulants

Where it's running

• IPO-Porto
  Porto, Portugal Recruiting

Study contacts

• Principal investigator: Pedro Pimentel-Nunes, MD PhD — Instituto Português de Oncologia do Porto, Francisco Gentil
• Study coordinator: Pedro Pimentel-Nunes, MD PhD
• Email: pedro.nunes@ipoporto.min-saude.pt
• Phone: +35122508400

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting gastric cancer risk in patients with intestinal metaplasia and atrophic gastritis

  This study is trying to find out which factors can help predict the risk of gastric cancer in patients who have intestinal metaplasia and atrophic gastritis.

  Recruiting Chinese University of Hong Kong · Shatin, New Territories · NCT04840056

• Breath testing for gastric cancer screening

  This study is testing if breath tests can help find gastric cancer and related conditions in people who have cancer, precancerous lesions, or are at average risk.

  Recruiting at 3 sites University of Latvia · São Paulo and 4 other locations · NCT04022109

• Mobile capsule gastroscopy for detecting stomach problems in older and high-risk people

  This project will test if an AI-assisted swallowable camera (mobile capsule gastroscopy) can find stomach diseases in older adults and people at higher risk.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07032961

• Registry and study on Helicobacter Pylori and related gastric conditions

  This study is trying to track how Helicobacter pylori infections affect the development of stomach problems, like pre-cancerous changes and cancer, in adults over time.

  Recruiting at 2 sites Chinese University of Hong Kong · Hong Kong and 1 other locations · NCT05053945

• Observational study on gastric precancerous conditions

  This study looks at people who are at higher risk for stomach cancer to see how conditions like atrophic gastritis and intestinal metaplasia develop over time.

  Recruiting Stanford University · Stanford, California · NCT04191551

• Monitoring patients with precancerous stomach lesions

  This study is trying to find out how to better monitor people with precancerous stomach lesions to see who is at risk of developing gastric cancer and when they should come back for check-ups.

  Recruiting University of Latvia · Riga · NCT03250091

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.