Innovative imaging techniques for assessing carotid atherosclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates new imaging biomarkers to evaluate carotid atherosclerosis, focusing on the vulnerability of atherosclerotic plaques. It aims to improve the understanding of plaque composition and its relationship to stroke risk by utilizing advanced imaging techniques such as High Resolution MRI and ultrasound examinations. The study includes patients with significant carotid stenosis and aims to differentiate between those who have experienced a stroke and those who have not, thereby enhancing risk assessment and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Carotid stenosis ≥ 50% NASCET
* Case: ipsilateral carotid stenosis stroke, certified by MRI or CT in the preceding month, with no others causes of stroke
* Control: no clinical sign or MRI hint for a recent stroke
* Signed informed consent form
* Patient affiliated to a social security system or equivalent

Exclusion Criteria:

* Modified Rankin scale \> 3
* Homolateral stroke or TIA \> 1 month
* Medical history of homolateral carotid surgery, cervical radiation, carotid occlusive, homolateral intracranial stenosis, risk of developing arterial thromboembolic events
* Renal failure (creatinine clearance \< 50 ml/min)
* Contraindication to ultrasound (sonovue)
* Contraindication to MRI and its contrast media (Gadolinium)
* Inability to sign informed consent
* Inability to undergo any of the technics (claustrophobia…)
* Serious co-morbid disease, dementia
* Neurological disease with no carotid disease
* Risk of pregnancy or pregnancy or breastfeeding
* Adult under reinforced guardianship or legal guardian
* Patient not understanding French

Where it's running

• Hospices Civils de Lyon - Service de radiologie
  Bron, France Recruiting

Study contacts

• Study coordinator: Philippe DOUEK, MD
• Email: philippe.douek@chu-lyon.fr
• Phone: (0)472357233

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Will GFAP in the blood after carotid endarterectomy predict neurological problems?

  This study tests whether blood GFAP levels before and after carotid endarterectomy relate to postoperative neurological issues in adults.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Bursa · NCT07843979

• Remote arm‑cuff conditioning plus stent placement for symptomatic carotid narrowing

  This study tests whether regular remote limb ischemic conditioning after carotid artery stenting can lower major vascular events and improve outcomes for adults with symptomatic carotid artery narrowing.

  Recruiting General Hospital of Shenyang Military Region · Shenyang · NCT07412249

• Residual and recurrent carotid narrowing after endarterectomy with primary closure

  The study will test how often and when carotid narrowing comes back after elective carotid endarterectomy with primary closure in adults.

  Recruiting Charles University, Czech Republic · Prague · NCT07057297

• Managing asymptomatic carotid stenosis to prevent strokes

  This study looks at whether surgery to clear blocked neck arteries can help older patients with no symptoms avoid strokes.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT06882954

• Selective coronary revascularization for patients with carotid artery disease after carotid surgery

  This study is testing if adding a specific heart procedure to the best medical treatment can help prevent heart problems in patients over 50 who have had surgery for carotid artery disease.

  Recruiting Pauls Stradins Clinical University Hospital · Riga · NCT06546761

• Carotid artery stenting during treatment of acute stroke

  This study is testing if adding carotid artery stenting during a stroke treatment can help improve blood flow to the brain and lower the chances of having another stroke for patients with blocked carotid arteries.

  Recruiting Phase 3 University Medical Center Groningen · Groningen · NCT06511089

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.