Will GFAP in the blood after carotid endarterectomy predict neurological problems?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center observational study will measure serum GFAP before surgery and 24 hours after carotid endarterectomy to see if levels associate with postoperative neurological complications. Researchers will collect perioperative data and monitor for events such as TIA, stroke, delirium, and cognitive dysfunction. Analyses will compare those who develop neurological issues with those who do not, using univariable and multivariable models. No treatment will be assigned; care is determined by the treating team. About 90 participants are planned at a single hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35 to 90 years
* Scheduled to undergo elective isolated carotid endarterectomy
* Willing and able to provide informed consent and the required blood samples

Exclusion Criteria:

* Acute coronary syndrome within the previous 3 months
* Carotid endarterectomy planned in combination with another surgical procedure
* Atrial fibrillation
* Known inflammatory disease
* Hematologic disease
* Refusal to provide preoperative consent or a blood sample
* Stroke with residual neurological sequelae within the previous year
* Multiple sclerosis, Alzheimer disease, Parkinson disease, or another pre-existing neurological disease

Where it's running

• University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital
  Bursa, Bursa, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Filiz Ata — Bursa Yuksek Ihtisas Training and Research Hospital
• Study coordinator: Filiz Ata
• Email: filizatafiliz@hotmail.com
• Phone: +90 505 631 49 68

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.