Residual and recurrent carotid narrowing after endarterectomy with primary closure
Official title: Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study
Run by Charles University, Czech Republic · NCT07057297 · Data updated 2026-11-12
The study will test how often and when carotid narrowing comes back after elective carotid endarterectomy with primary closure in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 1 site (Prague) |
| Status | Recruiting |
| Started | February 1, 2025 |
| Main results expected | January 1, 2026 |
| Study ends | January 1, 2027 |
| Registry record updated | July 9, 2025 |
| Trial ID | NCT07057297 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults meeting guideline indications for elective carotid endarterectomy who can provide informed consent and do not meet exclusion criteria are ideal candidates.
✕Probably not a fit
Patients who meet exclusion criteria (age ≤18 or ≥90, prior carotid endarterectomy or stent, unsuitable vascular anatomy, high perioperative risk, contralateral cranial nerve X/XII palsy, prior neck irradiation, tandem lesions or intracranial vascular pathology, or lacking consent) are unlikely to gain direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective multicenter observational tracking of patients undergoing elective carotid endarterectomy with primary closure at neurosurgical centers in the Czech Republic. Participants undergo preoperative CT angiography and standardized follow-up imaging at 30 days and one year to identify residual stenosis (≥50% within 30 days) and later restenosis. The protocol uses harmonized surgical technique and diagnostic algorithms across sites and collects clinical outcomes such as ischemic stroke, TIA, myocardial infarction, and mortality. Epidemiologic and laboratory risk factors as well as plaque calcification patterns are recorded to characterize predictors of restenosis.
Why it matters
Potential benefit: If successful, the project could give clearer, standardized data on how often narrowing recurs after primary-closure CEA and help refine follow-up and management plans.
How similar studies have gone: Previous observational series have reported variable restenosis rates after CEA, but this coordinated multicenter approach with standardized surgical and imaging protocols is relatively novel in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients without matching any of exclusion criteria who underwent cartotid endarterectomy Exclusion Criteria: Age ≤18 or ≥90 years Previous endarterectomy or stenting Unsuitable vascular anatomy High perioperative risk Contralateral cranial nerve X or XII palsy History of neck irradiation Tandem carotid stenosis or intracranial vascular pathology (e.g., aneurysm or AVM) Absence of signed informed consent
Where it's running
-
Central Military Hospital Prague
Prague, Czechia Recruiting
Study contacts
- Study coordinator: norbert Svoboda, MD
- Email: norbert.svoboda@uvn.cz
- Phone: +420973202963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.