Remote arm‑cuff conditioning plus stent placement for symptomatic carotid narrowing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults with recent ipsilateral cerebral ischemic symptoms and moderate-to-severe internal carotid artery stenosis who are scheduled for carotid artery stenting, and applies chronic remote ischemic conditioning after the procedure while monitoring patients over the long term. Remote ischemic conditioning (RIC) is a non-invasive approach that uses brief, repeated limb ischemia cycles to trigger protective mechanisms in the brain. The trial tracks incidence of major vascular events and clinical functional outcomes and records safety data related to prolonged RIC use. Results will determine whether chronic RIC adds long-term benefit to patients who receive carotid stents.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 years old;
* Patients with symptomatic moderate to severe stenosis of the internal carotid artery;
* History of ipsilateral cerebral ischemic symptoms within the past 180 days;
* Planned for carotid artery stent;
* Essen Score ≥ 3;
* Modified Rankin Scale score of 0 or 1;
* Signed informed consent.

Exclusion Criteria:

* Uncontrolled severe hypertension (systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg despite medication)
* Subclavian artery stenosis ≥ 50% or presence of subclavian steal syndrome
* Severe hematological disorders or significant coagulation abnormalities
* Contraindications to remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limbs, or peripheral vascular disease in the distal upper limbs
* Severe comorbid conditions with a life expectancy of less than 1 year
* Participation in another clinical trial within the past 3 months or ongoing participation
* Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.

Where it's running

• Department of Neurology, General Hospital of Northern Theater Command
  Shenyang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.