Injectable platelet-rich fibrin with a minimally invasive non-surgical technique for treating intrabony periodontal defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the adjunctive use of injectable platelet-rich fibrin (i-PRF) with a minimally invasive non-surgical technique (MINST) for regenerative treatment of intrabony periodontal defects. Participants are adults with periodontitis stage III (grades B or C), with bilateral comparable intrabony defects. The approach combines MINST to debride the defect with i-PRF to potentially enhance tissue regeneration, monitored clinically and radiographically. The study emphasizes soft tissue preservation and primary wound closure as key factors for optimal regeneration. Outcomes will inform whether i-PRF adds benefit over MINST alone in promoting periodontal regeneration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration.
* Diagnosis of 'periodontitis' stage III (grades B or C).
* Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.
* Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth.

Exclusion Criteria:

* Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.
* Pregnant and lactating women
* Current use of any form of tobacco.
* Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.
* Degree 2 or 3 mobility of the involved sites.6.
* Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.

Where it's running

• October 6 University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Amir R Elngar, B.D.S
• Email: amirreda059@gmail.com
• Phone: 00201004634587

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.