i-PRF bioactive matrix with coronally advanced flap vs connective tissue graft for gingival recessions
Official title: Efficacy of a Novel i-PRF-based Bioactive Matrix in the Treatment of Gingival Recessions: a Randomized Controlled Clinical Trial
Run by G. d'Annunzio University · NCT07918326 · Data updated 2026-11-12
This trial tests whether a bioactive matrix made with i-PRF and L-PRF, used with a coronally advanced flap, can provide similar or better root coverage than a traditional connective tissue graft in adults with Miller Class I or II gingival recessions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | G. d'Annunzio University Academic / other |
| Locations | 1 site (Chieti, Chieti) |
| Status | Recruiting |
| Started | February 12, 2024 |
| Main results expected | February 16, 2028 |
| Study ends | February 16, 2028 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07918326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with Miller Class I or II gingival recessions seeking treatment and meeting health and dental criteria.
✕Probably not a fit
Patients with compromised healing potential, active infections, or other exclusion factors may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares two surgical approaches for treating gingival recession: a coronally advanced flap with an i-PRF-based bioactive matrix and, in the control group, a coronally advanced flap with a connective tissue graft. Twenty-four adults with Miller Class I or II recessions will be randomized to receive either the bioactive matrix or the connective graft, with blinded examiners assessing root coverage at 6 months. Primary outcomes are mean and complete root coverage at 6 months; secondary outcomes include clinical parameters and patient-reported measures of post-operative discomfort and satisfaction at baseline, 3 months, and 6 months.
Why it matters
Potential benefit: If successful, patients may benefit from effective root coverage using a bioactive matrix that avoids harvesting autologous tissue.
How similar studies have gone: Previous studies in similar approaches show promising results for bioactive matrices in periodontal procedures, but this specific comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria Age ≥ 18 years Systemically healthy non-smokers Willingness to provide informed consent and attend the study No antibiotic use within the previous 3 months No known allergies to the materials used in the study No periodontal plastic surgery at the defect site within the previous 12 months Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) ≤ 20% Miller Class I or II (RT1) buccal gingival recessions at maxillary or mandibular incisors, canines or premolars, single or multiple Recession depth ≥ 2 mm Exclusion criteria Unstable systemic diseases Compromised healing potential (e.g. diabetes) Active infectious diseases (hepatitis, tuberculosis, HIV, etc.) Use of steroid medications Pregnancy or attempting to become pregnant Use of medications known to cause gingival enlargement
Where it's running
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Department of Innovative Technologies in Medicine and Dentistry, University 'G. D'Annunzio' of Chieti
Chieti, Chieti, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.