Injectable platelet-rich fibrin for faster orthodontic tooth movement
Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description
This study is testing if an injectable treatment made from platelets can help speed up tooth movement for people getting braces.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 26 Years |
| Sex | All |
| Sponsor | Hama University Academic / other |
| Locations | 1 site (Hama) |
| Trial ID | NCT06302296 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effect of injectable platelet-rich fibrin (i-PRF) on accelerating orthodontic tooth movement, specifically focusing on the leveling of maxillary incisors during comprehensive orthodontic treatment. The study is randomized and compares the effects of i-PRF against a placebo injection. The use of i-PRF is based on its higher regenerative properties due to a unique preparation method that utilizes low centrifugation speed, which preserves more growth factors and regenerative cells. The goal is to determine if i-PRF can significantly reduce treatment time for patients undergoing orthodontic procedures.
Who should consider this trial
Good fit: Ideal candidates are young adults aged 18-26 with specific orthodontic needs, including severe irregularity of upper incisors and Class I or II malocclusion.
Not a fit: Patients with systemic diseases affecting tooth movement or those who have previously undergone orthodontic treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly shorten the duration of orthodontic treatment for patients.
How similar studies have performed: Previous studies on platelet-rich fibrin in orthodontics have shown limited results, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar. * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern. * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position. * The patient has good oral health. Exclusion Criteria: * • The presence of any systemic disease that affects orthodontic dental movement. * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar). * The patient has undergone previous orthodontic treatment. * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs). * The patient has poor oral health. * Commitment to periodic follow-up appointments.
Where this trial is running
Hama
- Fadi Jnaid — Hama, Syria (Recruiting)
Study contacts
- Principal investigator: Eisa Salami, MSc student — Hama University
- Study coordinator: FADI JNAID, Associate Professor
- Email: Drfadijnaid@gmail.com
- Phone: 988499015
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.