Injectable platelet-rich fibrin for faster orthodontic tooth movement
Official title: Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description
Run by Hama University · NCT06302296 · Data updated 2026-11-12
This study is testing if an injectable treatment made from platelets can help speed up tooth movement for people getting braces.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 26 Years |
| Sex | All |
| Enrollment | 14 (estimated) |
| Sponsor | Hama University Academic / other |
| Locations | 1 site (Hama) |
| Status | Recruiting |
| Started | December 20, 2026 |
| Main results expected | May 15, 2027 |
| Study ends | July 15, 2027 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT06302296 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young adults aged 18-26 with specific orthodontic needs, including severe irregularity of upper incisors and Class I or II malocclusion.
✕Probably not a fit
Patients with systemic diseases affecting tooth movement or those who have previously undergone orthodontic treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effect of injectable platelet-rich fibrin (i-PRF) on accelerating orthodontic tooth movement, specifically focusing on the leveling of maxillary incisors during comprehensive orthodontic treatment. The study is randomized and compares the effects of i-PRF against a placebo injection. The use of i-PRF is based on its higher regenerative properties due to a unique preparation method that utilizes low centrifugation speed, which preserves more growth factors and regenerative cells. The goal is to determine if i-PRF can significantly reduce treatment time for patients undergoing orthodontic procedures.
Why it matters
Potential benefit: If successful, this approach could significantly shorten the duration of orthodontic treatment for patients.
How similar studies have gone: Previous studies on platelet-rich fibrin in orthodontics have shown limited results, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar. * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern. * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position. * The patient has good oral health. Exclusion Criteria: * • The presence of any systemic disease that affects orthodontic dental movement. * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar). * The patient has undergone previous orthodontic treatment. * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs). * The patient has poor oral health. * Commitment to periodic follow-up appointments.
Where it's running
-
Fadi Jnaid
Hama, Syria Recruiting
Study contacts
- Principal investigator: Eisa Salami, MSc student — Hama University
- Study coordinator: FADI JNAID, Associate Professor
- Email: Drfadijnaid@gmail.com
- Phone: 988499015
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.