Injectable Platelet-Rich Fibrin Added to MINST for Grade II Furcation Defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial compares MINST alone to MINST plus injectable platelet-rich fibrin (i-PRF) for managing class II furcation defects in adults with Stage III, Grade B periodontitis. It uses magnification during debridement to preserve tissue and enhance root decontamination, with the experimental arm receiving i-PRF to potentially boost regenerative outcomes. Outcomes will be assessed clinically and radiographically to determine whether the combination improves tissue stability and defect resolution. The study is conducted at October 6 University, with participants meeting specific inclusion criteria and agreeing to ongoing maintenance follow-up. The design focuses on real-world applicability of a minimally invasive approach augmented by a biologic agent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration.
* Diagnosis of stage III, grade B periodontitis (according to the AAP/EFP classification 2018) with the presence of class II furcation defect in either the maxillary (buccal) or mandibular arch (buccal or lingual) as determined by clinical evaluation and confirmed by radiographic evaluation.
* Gingival margin and interdental bone positioned coronally to the furcation entrance.
* Commitment to maintenance visits and follow-up.
* Absence of primary endodontic lesions.

Exclusion Criteria:

* Patients suffering from any systemic diseases that may affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc;
* Patients that received periodontal surgical treatments in the past 12 months.
* Smoking (current or in past 5 years)
* Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months prior to periodontal therapy.
* Pregnant and lactating females.
* Teeth with hopeless prognosis
* Third molars

Where it's running

• October 6 University (Faculty of Dentistry)
  Giza, Giza Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Moustafa A Ahmed, B.D.S
• Email: 23110295.pg@o6u.edu.eg
• Phone: 00201098378998

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Injectable platelet-rich fibrin for faster orthodontic tooth movement

  This study is testing if an injectable treatment made from platelets can help speed up tooth movement for people getting braces.

  Recruiting Hama University · Hama · NCT06302296

• Bone substitutes with NIPSA for intrabony periodontal defects

  This study tests two bone substitutes (GTO and GenOs) used with the NIPSA technique to see which supports better gum and bone healing in adults with Stage III periodontitis.

  Recruiting at 2 sites University of Belgrade · Cagliari, Italy and 1 other locations · NCT07671963

• Renal perfusion during minimally invasive abdominal surgery using ultrasound and NIRS

  Researchers will test if Doppler ultrasound RRI and NIRS-based rSO₂ can detect changes in kidney perfusion during elective laparoscopic surgery in adults with varying health status.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07635160

• Comparing postoperative pain after robotic versus laparoscopic colorectal surgery

  We will test whether robotic surgery causes less pain than laparoscopic surgery for adults having elective colon (right or left hemicolectomy) operations who meet the hospital's enhanced recovery (RICA) protocol.

  Recruiting Hospital Central de la Defensa Gómez Ulla · Madrid · NCT07431892

• Comparing two surgical approaches for lymphadenectomy in endometrial cancer

  This study is testing two different surgical methods for removing lymph nodes in women with early-stage endometrial cancer to see which one works better.

  Recruiting Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır, Baglar · NCT06870903

• Evaluating pain management methods for minimally invasive cancer surgery

  This study is testing which pain management method works best for people undergoing minimally invasive cancer surgery by comparing three different approaches.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT06731998

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.