Alveolar Bone Regeneration with Advanced Platelet-Rrich Fibrin and Strontium-Doped Hydroxyapatite

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares three approaches for preserving the tooth extraction socket: A-PRF alone, A-PRF combined with Sr-HA, and spontaneous healing without graft material. The goal is to see which method best supports alveolar bone regeneration. A-PRF provides a fibrin matrix rich in platelets and cells, while Sr-HA is a bone substitute designed to enhance remodeling. Participants are adults needing tooth extractions with intact sockets and adequate surrounding bone walls. Outcomes focus on bone regeneration and healing in the extraction sites over follow-up visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 60 years.
* Both male and female patients.
* Indicated for extraction of teeth with preservation of intact extraction sockets.
* Presence of adequate surrounding bone walls suitable for socket preservation.
* Good oral hygiene and acceptable plaque control.
* Systemically healthy patients or those with medically controlled conditions that do not interfere with bone healing.
* Ability and willingness to comply with the study protocol and follow-up visits.

Exclusion Criteria:

* Pregnancy or lactation.
* Current smokers or tobacco users.
* Uncontrolled diabetes mellitus or systemic diseases affecting bone metabolism or wound healing.
* History of radiotherapy or chemotherapy involving the head and neck region.
* Active acute infection at the extraction site.
* History of bisphosphonate therapy or long-term corticosteroid use.
* Bleeding disorders or anticoagulant therapy contraindicating blood collection.
* Previous regenerative procedures at the intended surgical site within the preceding six months.
* Patients unable or unwilling to attend scheduled follow-up visits.

Where it's running

• Kafr Elsheikh University
  Kafr ash Shaykh, Kafr Elsheikh, Egypt Recruiting

Study contacts

• Study coordinator: Abdulkarim J Al-Jahed, B.Sc
• Email: dr.abdulkareemaljahed@gmail.com
• Phone: 00201121618187

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.