MINST with or without e-PRF for intrabony periodontal defects

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with stage III periodontitis and at least two intrabony defects in different quadrants are randomized to MINST alone or MINST plus e-PRF. The procedure uses careful, tissue-sparing root surface instrumentation with magnification, followed by injection of the patient’s own e-PRF in the test group. The study aims to compare bone regeneration and gingival healing between the two approaches. Eligibility requires PD ≥ 6 mm and radiographic defects of 3–7 mm, with several exclusion criteria to minimize confounding factors. The trial is conducted at the Cairo University Faculty of Dentistry.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged above 21 years. Clinical diagnosis of Stage III periodontitis. Presence of at least two isolated interproximal intrabony defects located in different quadrants.

Intrabony defect associated with a single-rooted tooth or mandibular molar without furcation involvement.

Probing depth (PD) ≥ 6 mm. Radiographic intrabony defect depth between 3 and 7 mm. Absence of periapical pathology at the study site. Absence of acute periodontal infection. Absence of subgingival restorations that could interfere with clinical measurements.

Absence of Grade II or Grade III tooth mobility. Ability and willingness to provide written informed consent.

Exclusion Criteria:

Pregnancy or lactation. Non-surgical periodontal therapy within the previous 6 months. Surgical periodontal therapy within the previous 12 months. History of radiotherapy to the head and neck region. Current smoking.

Eligibility note: Former smokers and never-smokers are eligible.

Where it's running

• Faculty of Dentistry, Cairo University
  Giza, Giza Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Samuel Michael Mikhail, B.Sc.
• Email: samuel.girgis@dentistry.cu.edu.eg
• Phone: +201117776200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.