Exploring the impact of maternal grandmothers on child health in Guangzhou
Official title: Maternal Grandmothers in the Born in Guangzhou Cohort Study
Run by Guangzhou Women and Children's Medical Center · NCT03633162 · Data updated 2026-11-12
This study looks at how maternal grandmothers in Guangzhou, China, might affect the health of their grandchildren by examining both genetics and lifestyle factors.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 36 Years to 100 Years |
| Sex | Women only |
| Enrollment | 5000 (estimated) |
| Sponsor | Guangzhou Women and Children's Medical Center Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | May 21, 2018 |
| Main results expected | December 31, 2038 |
| Study ends | December 31, 2038 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT03633162 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are maternal grandmothers of children born at the Guangzhou Women and Children's Medical Center.
✕Probably not a fit
Patients with significant cardiovascular abnormalities or intellectual disabilities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The MGBIG study investigates the cross-generational effects of maternal grandmothers on the health of their grandchildren in Guangzhou, China. It aims to understand how genetic and environmental factors influence disease development across three generations: grandmother, mother, and child. The study collects extensive data on lifestyle, environmental exposures, and health history, along with biological samples from participants. By focusing on this unique cohort, the research seeks to uncover the role of maternal grandmothers in shaping the health outcomes of future generations.
Why it matters
Potential benefit: If successful, this study could provide insights into how maternal grandmothers influence the health and development of their grandchildren, potentially leading to improved health strategies.
How similar studies have gone: While the concept of cross-generational health effects is gaining attention, this specific approach focusing on maternal grandmothers is relatively novel and has not been extensively tested in similar studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center 2. Baseline information of maternal grandmother's daughter during pregnancy available Exclusion Criteria: 1. Significant cardiovascular abnormalities 2. Intelligent obstacle, intellectual disabilities or gawkish condition
Where it's running
-
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Xiu Qiu, PhD — Guangzhou Women and Children's Medical Center, China
- Study coordinator: Xiu Qiu, PhD
- Email: qxiu0161@163.com
- Phone: 0086 20 38367160
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.