Research on twins born in Guangzhou
Official title: Twins Born in Guangzhou Cohort Study
Run by Guangzhou Women and Children's Medical Center · NCT03331133 · Data updated 2026-11-12
This study is trying to understand how genes and the environment affect diseases by looking at twins born in Guangzhou, China, from birth to age 18.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Guangzhou Women and Children's Medical Center Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | February 1, 2012 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2038 |
| Registry record updated | February 26, 2024 |
| Trial ID | NCT03331133 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are live twins born at the Guangzhou Women and Children's Medical Center who are permanent residents or families intending to stay in Guangzhou for at least three years.
✕Probably not a fit
Patients who do not meet the residency requirement or are not twins born in the specified medical center may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The 2-BIG is a twin birth cohort study based in Guangzhou, China, aimed at understanding how genetic and environmental factors contribute to diseases. It collects extensive data on twins from birth to 18 years, including biological samples and information on family and lifestyle exposures. By utilizing a twin cohort, the study seeks to minimize biases related to age, gender, and environment, allowing for a clearer analysis of disease etiology. The research focuses on chronic diseases and aims to establish a database for calculating the heritability of traits in the Chinese population.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of disease development in twins, potentially leading to improved prevention and treatment strategies.
How similar studies have gone: While twin studies are common in various populations, this specific cohort study in China is relatively rare and aims to provide novel insights into the heritability of traits associated with chronic diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Live twins delivered in Guangzhou Women and Children's Medical Center 2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years 3. Baseline information during pregnancy available
Where it's running
-
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Xiu Qiu, PhD — Born in Guangzhou Cohort Study in Guangzhou Women and Children's Medical Center
- Study coordinator: Xiu Qiu, PhD
- Email: xiu.qiu@bigcs.org/qxiu0161@163.com
- Phone: 0086 20 38367162
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Understanding the effects of gestational diabetes on mothers and their children
This study looks at how gestational diabetes affects the health of mothers and their children both during and after pregnancy to find ways to reduce health risks.
-
Exploring the impact of maternal grandmothers on child health in Guangzhou
This study looks at how maternal grandmothers in Guangzhou, China, might affect the health of their grandchildren by examining both genetics and lifestyle factors.
-
Investigating early life exposures and their health effects in Guangzhou
This study looks at how early life experiences, like the environment and lifestyle, affect the health of mothers and their children in Guangzhou, China, especially concerning issues like high blood sugar during pregnancy and childhood obesity.
-
Exploring the impact of maternal microbiota on child health
This study looks at how the bacteria in pregnant women's bodies affect their babies' health and development to see if it can help prevent future health issues.
-
Exploring factors affecting preterm birth and its outcomes in children
This study is looking at how genetics and the environment affect preterm birth and its impact on the health of children over time.
-
Investigating the health effects of IVF on mothers and their children in Guangzhou
This study is trying to see how having babies through IVF affects the health of mothers and their children over time.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.